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Mouse Anti-MICAL3 (AA 251-340) Recombinant Antibody (CBFYM-2214) (CBMAB-M2397-FY)

This product is mouse antibody that recognizes MICAL3. The antibody CBFYM-2214 can be used for immunoassay techniques such as: ELISA, WB.
See all MICAL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2214
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: DDQHWSDSPS DADRELRLPC PAEGEAELEL RVSEDEEKLP ASPKHQERGP SQATSPIRSP QESALLFIPV HSPSTEGPQL PPVPAATQEK
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 251-340

Target

Full Name
microtubule associated monoxygenase, calponin and LIM domain containing 3
Introduction
MICAL3 is a Protein Coding gene. Gene Ontology annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MICAL2.
Entrez Gene ID
57553
UniProt ID
Q7RTP6
Alternative Names
Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3; Molecule Interacting With CasL Protein 3; MICAL-3; [F-Actin]-Methionine Sulfoxide Oxidase MICAL3; Protein-Methionine Sulfoxide Oxidase MICAL3; Flavoprotein Oxidoreductase MICAL3
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H2O2. Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Biological Process
Actin filament depolymerization Source: UniProtKB
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cytoskeleton organization Source: UniProtKB
Exocytosis Source: UniProtKB-KW
Cellular Location
Nucleus
Cytoskeleton
spindle
cilium basal body
Cytoplasm 1 Publication
Other locations
cell cortex
Midbody
Note: Mainly localizes in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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