MICAL3

MICAL3 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MICAL2.

Full Name

microtubule associated monoxygenase, calponin and LIM domain containing 3

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H2O2. Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.

Biological Process

Actin filament depolymerization Source: UniProtKB
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cytoskeleton organization Source: UniProtKB
Exocytosis Source: UniProtKB-KW

Cellular Location

Nucleus
Cytoskeleton
spindle
cilium basal body
Cytoplasm 1 Publication
Other locations
cell cortex
Midbody
Note: Mainly localizes in the nucleus.