Mouse Anti-MIS12 Recombinant Antibody (2572C2a) (CBMAB-M2423-FY)

Name: Mouse Anti-MIS12 Recombinant Antibody (2572C2a)
SKU: CBMAB-M2423-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2572C2a

Application

Dot

Immunogen

Recombinant Human Mis12, Mind Kinetochore Complex Component, Homolog (S.Pombe) (Mis12)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MIS12, MIND kinetochore complex component, homolog (yeast)

Introduction

MIS12 is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Cell Cycle, Mitotic.

Entrez Gene ID

79003

UniProt ID

Q9H081

Alternative Names

MIS12, Kinetochore Complex Component; MIS12, MIND Kinetochore Complex Component, Homolog (S. Pombe); MIS12, MIND Kinetochore Complex Component, Homolog (Yeast); MIS12, MIND Kinetochore Complex Component, Homolog; Homolog Of Yeast Mis12; Protein MIS12 Homolog

Function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270).

Essential for proper kinetochore microtubule attachments (PubMed:23891108).

Biological Process

Attachment of mitotic spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Chromosome segregation Source: UniProtKB
Kinetochore assembly Source: UniProtKB
Mitotic sister chromatid segregation Source: GO_Central
Protein localization to kinetochore Source: GO_Central

Cellular Location

Other locations
kinetochore
Note: Associated with the kinetochore.

Guo, Y. (2019). The Architectural Changes of Mis12 Complex under Different Tension Levels (Doctoral dissertation, Johns Hopkins University).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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