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Mouse Anti-MKNK2 Recombinant Antibody (4F11) (CBMAB-A5504-LY)

The product is antibody recognizes MKNK2. The antibody 4F11 immunoassay techniques such as: WB, ELISA.
See all MKNK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4F11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MKNK2 (AAH18345, 1 a.a. ~ 158 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAP kinase interacting serine/threonine kinase 2
Entrez Gene ID
Human2872
Mouse17347
Rat299618
UniProt ID
HumanQ9HBH9
MouseQ8CDB0
RatQ5U2N4
Alternative Names
GPRK7; MNK2
Function
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to arsenic-containing substance Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Hemopoiesis Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Peptidyl-serine phosphorylation Source: GO_Central
Protein autophosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
Cellular Location
Isoform 2:
Nucleus
PML body
Isoform 1:
Cytoplasm
PTM
Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As2O3 treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.

Aijaz, A., Padilla, I., & Smith, K. (2023). Activity of MKNK2 Isoforms Studied by Phosphorylation with p38a-MAPK.

Kuang, P., Zhang, J., Wan, F., Zhang, Y., Zhang, W., & Zhang, X. (2023, May). MKNK2 as A Prognosis-Related Biomarker for Gastric Cancer. In Proceedings of the 2023 15th International Conference on Bioinformatics and Biomedical Technology (pp. 61-68).

Vaughan, N., Collier, A., Harrell, J., & Clark, A. (2023). Expression of MKNK2 Isoforms in Cancer Cell Lines.

Stefanie, A., & Diaz, M. (2023). Endogenous levels of MKNK2 Isoforms in Normal and Cancer Cell Lines.

Phan, V., & Silva, A. (2023). Comparison of MKNK2 Isoform Levels in Normal and Cancer Cells.

Huang, B., Guo, S., Zhang, Y., Lin, P., Lin, C., Chen, M., ... & Wen, Z. (2022). MiR‐223‐3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling. Brain and Behavior, 12(7), e2634.

Wang, J., Da, C., Su, Y., Song, R., & Bai, Z. (2021). MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b. Biochemical and Biophysical Research Communications, 556, 31-38.

Liu, H., Gong, Z., Li, K., Zhang, Q., Xu, Z., & Xu, Y. (2021). SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Qin, M., Liang, Z., Qin, H., Huo, Y., Wu, Q., Yang, H., & Tang, G. (2021). Novel prognostic biomarkers in gastric cancer: CGB5, MKNK2, and PAPPA2. Frontiers in Oncology, 11, 683582.

Liu, B., Sun, Y., Tang, M., Liang, C., Huang, C. P., Niu, Y., ... & Chang, C. (2020). The miR-361-3p increases enzalutamide (Enz) sensitivity via targeting the ARv7 and MKNK2 to better suppress the Enz-resistant prostate cancer. Cell Death & Disease, 11(9), 807.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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