Mouse Anti-MLXIP Antibody (1A10) (CBMAB-0681-YC)

Provided herein are mouse monoclonal antibodies against Human MLXIP. The antibody clone 1A10 can be used for immunoassay techniques, such as IP and MA.
See all MLXIP antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A10

Antibody Isotype

IgG2c

Application

IP, MA

Basic Information

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2c

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MLXIP

Introduction

MLXIP (MLX interacting protein) is a protein that functions as part of a heterodimer to activate transcription. MLXIP forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels.

Entrez Gene ID

22877

UniProt ID

Q9HAP2

Alternative Names

bHLHe36; KIAA0867; MIR; MONDOA

Function

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm
Nucleus
Mitochondrion
Mitochondrion outer membrane
Note: Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus.

References

Wang, F., Chen, S., Peng, S., Zhou, X., Tang, H., Liang, H., ... & Cui, H. (2023). PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway. Genes & Diseases.

Sipol, A., Hameister, E., Petry, A., Görlach, A., Ruland, J., Richter, G., ... & Sorensen, P. (2020). Abstract B51: Adaptation to oncogene-induced metabolic stress by MondoA (MLXIP) drives common acute lymphoblastic leukemia (cALL) malignancy. Cancer Research, 80(14_Supplement), B51-B51.

Jaworek, T., Kittner, S. J., Jern, C., de Leeuw, F. E., Dichgans, M., Malik, R., ... & Salomaa, V. (2020). Genome-wide Association Study of Early-Onset Ischemic Stroke Identifies Novel Locus on Chromosome 12 Near BCL7A/MLXIP. Stroke, 51(Suppl_1), A152-A152.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MLXIP (AA 481-577) Recombinant Antibody (CBFYM-2316)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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