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Mouse Anti-MMP11 Recombinant Antibody (CBFYM-2352) (CBMAB-M2538-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Pig
Clone
CBFYM-2352
Antibody Isotype
IgG1
Application
IHC-Fr, IHC-P

Basic Information

Immunogen
Full length recombinant Human Stromelysin-3. Antigen, epitope: The epitope has not been further characterized
Specificity
Human, Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Matrix Metallopeptidase 11
Introduction
Proteins of the matrix metalloproteinase family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Entrez Gene ID
Human4320
Pig100153503
UniProt ID
HumanP24347
PigF1RL22
Alternative Names
Matrix Metallopeptidase 11; STMY3; SL-3; ST3; Matrix Metalloproteinase 11 (Stromelysin 3); Matrix Metallopeptidase 11 (Stromelysin 3); Matrix Metalloproteinase-11; Stromelysin III
Function
May play an important role in the progression of epithelial malignancies.
Biological Process
Basement membrane organization Source: Ensembl
Collagen catabolic process Source: GO_Central
Collagen fibril organization Source: Ensembl
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Multicellular organism development Source: ProtInc
Negative regulation of fat cell differentiation Source: Ensembl
Proteolysis Source: ProtInc
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
More Infomation

Kang, S. U., Cho, S. Y., Jeong, H., Han, J., Chae, H. Y., Yang, H., ... & Kwon, M. J. (2022). Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2–CCR2 signaling. Laboratory investigation, 102(4), 376-390.

Ma, B., Ran, R., Liao, H. Y., & Zhang, H. H. (2021). The paradoxical role of matrix metalloproteinase-11 in cancer. Biomedicine & Pharmacotherapy, 141, 111899.

Medina-González, A., Eiró-Díaz, N., Fernández-Gómez, J. M., Ovidio-González, L., Jalón-Monzón, A., Casas-Nebra, J., & Escaf-Barmadah, S. (2020). Comparative analysis of the expression of metalloproteases (MMP-2, MMP-9, MMP-11 and MMP-13) and the tissue inhibitor of metalloprotease 3 (TIMP-3) between previous negative biopsies and radical prostatectomies. Actas Urológicas Españolas (English Edition), 44(2), 78-85.

Chen, C., Liu, X., Jiang, J., Li, S., Wang, G., Ju, L., ... & Li, S. (2020). Matrix metalloproteinase 11 is a potential biomarker in bladder cancer diagnosis and prognosis. OncoTargets and therapy, 9059-9069.

Zhang, X., Lu, J., Zhou, L., You, L., Liang, Z., Guo, J., & Zhao, Y. (2020). Matrix metalloproteinase 11 as a novel tumor promoter and diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. Pancreas, 49(6), 812-821.

Eiro, N., Cid, S., Fernández, B., Fraile, M., Cernea, A., Sánchez, R., ... & Vizoso, F. J. (2019). MMP11 expression in intratumoral inflammatory cells in breast cancer. Histopathology, 75(6), 916-930.

González de Vega, R., Clases, D., Fernández-Sánchez, M. L., Eiró, N., González, L. O., Vizoso, F. J., ... & Sanz-Medel, A. (2019). MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry. Analytical and bioanalytical chemistry, 411, 639-646.

Lee, J., Lee, J., & Kim, J. H. (2019). Identification of matrix metalloproteinase 11 as a prognostic biomarker in pancreatic cancer. Anticancer Research, 39(11), 5963-5971.

Yang, H., Jiang, P., Liu, D., Wang, H. Q., Deng, Q., Niu, X., ... & Yang, W. (2019). Matrix metalloproteinase 11 is a potential therapeutic target in lung adenocarcinoma. Molecular Therapy-Oncolytics, 14, 82-93.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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