MMP11

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Matrix Metallopeptidase 11

May play an important role in the progression of epithelial malignancies.

Basement membrane organization Source: Ensembl
Collagen catabolic process Source: GO_Central
Collagen fibril organization Source: Ensembl
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Multicellular organism development Source: ProtInc
Negative regulation of fat cell differentiation Source: Ensembl
Proteolysis Source: ProtInc

Extracellular matrix

The precursor is cleaved by a furin endopeptidase.