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Rabbit Anti-MMP12 Recombinant Antibody (CBFYM-2355) (CBMAB-M2541-FY)

This product is rabbit antibody that recognizes MMP12. The antibody CBFYM-2355 can be used for immunoassay techniques such as: WB, IHC-P, IF, IP, FC.
See all MMP12 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYM-2355
Antibody Isotype
IgG
Application
WB, IHC-P, IF, IP, FC

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH 7.4, 1% BSA, 40% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Matrix Metallopeptidase 12
Introduction
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease. This gene is part of a cluster of MMP genes on chromosome 11.
Entrez Gene ID
Human4321
Mouse17381
Rat117033
UniProt ID
HumanP39900
MouseP34960
RatQ63341
Alternative Names
Matrix Metallopeptidase 12; Matrix Metalloproteinase 12 (Macrophage Elastase); Macrophage Elastase; EC 3.4.24.65; MMP-12; HME; MME
Function
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Biological Process
Bronchiole development Source: Ensembl
Cellular response to virus Source: Ensembl
Collagen catabolic process Source: GO_Central
Elastin catabolic process Source: ARUK-UCL
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Lung alveolus development Source: Ensembl
Negative regulation of endothelial cell-matrix adhesion via fibronectin Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
Positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
Positive regulation of interferon-alpha production Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: CAFA
Positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
Protein import into nucleus Source: CAFA
Proteolysis Source: CAFA
Regulation of defense response to virus by host Source: Ensembl
Response to amyloid-beta Source: ARUK-UCL
Wound healing, spreading of epidermal cells Source: BHF-UCL
Cellular Location
Extracellular matrix

Kuntschar, S., Cardamone, G., Klann, K., Bauer, R., Meyer, S. P., Raue, R., ... & Schmid, T. (2023). Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation. International Journal of Molecular Sciences, 24(23), 16981.

Cárcel-Márquez, J., Cullell, N., Muiño, E., Gallego-Fabrega, C., Lledós, M., Ibañez, L., ... & Fernandez-Cadenas, I. (2021). Causal effect of MMP-1 (matrix metalloproteinase-1), MMP-8, and MMP-12 levels on ischemic stroke: a Mendelian randomization study.

Gao, H., Zhou, X., Li, H., Liu, F., Zhu, H., Song, X., ... & Lu, J. (2021). Role of matrix metallopeptidase 12 in the development of hepatocellular carcinoma. Journal of Investigative Surgery, 34(4), 366-372.

Nighot, M., Ganapathy, A. S., Saha, K., Suchanec, E., Castillo, E. F., Gregory, A., ... & Nighot, P. (2021). Matrix metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis. Journal of Crohn's and Colitis, 15(10), 1751-1765.

Mohan, A., Neequaye, N., Malur, A., Soliman, E., McPeek, M., Leffler, N., ... & Thomassen, M. J. (2020). Matrix metalloproteinase-12 is required for granuloma progression. Frontiers in Immunology, 11, 553949.

Yang, H., Zhang, C., Wu, J., Xiao, W., Xie, X., Zeng, Z., ... & Huang, Q. (2020). Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol for systematic review and meta analysis. Medicine, 99(31).

Lulińska, E., Gibbon, A., Kaczmarczyk, M., Maciejewska-Skrendo, A., Ficek, K., Leońska-Duniec, A., ... & Sawczuk, M. (2020). Matrix metalloproteinase genes (Mmp1, mmp10, mmp12) on chromosome 11q22 and the risk of non-contact anterior cruciate ligament ruptures. Genes, 11(7), 766.

Toczek, J., Bordenave, T., Gona, K., Kim, H. Y., Beau, F., Georgiadis, D., ... & Devel, L. (2019). Novel matrix metalloproteinase 12 selective radiotracers for vascular molecular imaging. Journal of medicinal chemistry, 62(21), 9743-9752.

Li, B., Hu, L., Xue, Y., Yang, M., Huang, L., Zhang, Z., ... & Deng, G. (2019). Prediction of matrix metal proteinases-12 inhibitors by machine learning approaches. Journal of Biomolecular Structure and Dynamics, 37(10), 2627-2640.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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