MMP12

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Full Name
Matrix Metallopeptidase 12
Function
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Biological Process
Bronchiole development Source: Ensembl
Cellular response to virus Source: Ensembl
Collagen catabolic process Source: GO_Central
Elastin catabolic process Source: ARUK-UCL
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Lung alveolus development Source: Ensembl
Negative regulation of endothelial cell-matrix adhesion via fibronectin Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
Positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
Positive regulation of interferon-alpha production Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: CAFA
Positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
Protein import into nucleus Source: CAFA
Proteolysis Source: CAFA
Regulation of defense response to virus by host Source: Ensembl
Response to amyloid-beta Source: ARUK-UCL
Wound healing, spreading of epidermal cells Source: BHF-UCL
Cellular Location
Extracellular matrix
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Anti-MMP12 antibodies

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Rabbit Anti-MMP12 Recombinant Antibody (A1140) (CBMAB-AP11880LY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1140
Application*: FC, ICC, IF, IHC, WB
Datasheet SDS

Rabbit Anti-MMP12 Recombinant Antibody (A1138) (CBMAB-AP11884LY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1138
Application*: FC, ICC, IHC, IP, WB
Datasheet SDS

Rabbit Anti-MMP12 Recombinant Antibody (RM381) (CBMAB-BR356LY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM381
Application*: IHC, WB
Datasheet SDS

Recombinant Rabbit Anti-MMP12 Antibody (CBAb169) (CBMAB-Ab169-LY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb169
Application*: WB, IH
Datasheet SDS

Rabbit Anti-MMP12 Recombinant Antibody (CBFYM-2355) (CBMAB-M2541-FY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-2355
Application*: WB, P, IF, IP, F
Datasheet SDS

Mouse Anti-MMP12 Recombinant Antibody (CBFYM-2354) (CBMAB-M2540-FY)

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Target: MMP12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBFYM-2354
Application*: F, E, IH, P, C
Datasheet SDS

Mouse Anti-MMP12 Recombinant Antibody (CBFYM-2353) (CBMAB-M2539-FY)

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Target: MMP12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2353
Application*: WB, IH, IP
Datasheet SDS

Rabbit Anti-MMP12 Recombinant Antibody (CBFYM-0280) (CBMAB-M0345-FY)

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Target: MMP12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0280
Application*: IF
Datasheet SDS

Mouse Anti-MMP12 Recombinant Antibody (CBFYM-0199) (CBMAB-M0239-FY)

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Target: MMP12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0199
Application*: E
Datasheet SDS

Mouse Anti-MMP12 Recombinant Antibody (CBFYM-0182) (CBMAB-M0215-FY)

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Target: MMP12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0182
Application*: IH, C
Datasheet SDS

Mouse Anti-MMP12 Recombinant Antibody (A1139) (CBMAB-AP11885LY)

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Target: MMP12
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: A1139
Application*: IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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