MMP12

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Matrix Metallopeptidase 12

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Bronchiole development Source: Ensembl
Cellular response to virus Source: Ensembl
Collagen catabolic process Source: GO_Central
Elastin catabolic process Source: ARUK-UCL
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Lung alveolus development Source: Ensembl
Negative regulation of endothelial cell-matrix adhesion via fibronectin Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
Positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
Positive regulation of interferon-alpha production Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: CAFA
Positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
Protein import into nucleus Source: CAFA
Proteolysis Source: CAFA
Regulation of defense response to virus by host Source: Ensembl
Response to amyloid-beta Source: ARUK-UCL
Wound healing, spreading of epidermal cells Source: BHF-UCL

Extracellular matrix