Rat Anti-MMP24 (AA 125-296) Recombinant Antibody (CBFYM-0056) (CBMAB-M0062-FY)

Name: Rat Anti-MMP24 (AA 125-296) Recombinant Antibody (CBFYM-0056)
SKU: CBMAB-M0062-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-0056

Application

Immunogen

E. coli-derived recombinant mouse MMP-24/MT5-MMP, Arg125-Gln296

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 125-296

More Infomation

Target

Full Name

MATRIX METALLOPEPTIDASE 24

Introduction

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2.

Entrez Gene ID

Human	10893
Mouse	17391

UniProt ID

Human	Q9Y5R2
Mouse	Q9R0S2

Alternative Names

Matrix Metallopeptidase 24; Matrix Metalloproteinase 24 (Membrane-Inserted); Matrix Metallopeptidase 24 (Membrane-Inserted); Membrane-Type 5 Matrix Metalloproteinase; Membrane-Type Matrix Metalloproteinase 5; MT-MMP 5; MT5-MMP; MMP-24; MT5MMP

Function

Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Biological Process

Cell-cell adhesion mediated by cadherin Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Collagen catabolic process Source: GO_Central
Detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Glial cell differentiation Source: UniProtKB
Neuronal stem cell population maintenance Source: UniProtKB
Proteolysis Source: UniProtKB

Cellular Location

Matrix metalloproteinase-24:
Plasma membrane
Cell membrane
Golgi apparatus
trans-Golgi network membrane
Note: Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3.
Processed matrix metalloproteinase-24:
Extracellular region or secreted
extracellular matrix
Note: Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.

Topology

Extracellular: 53-602
Helical: 603-623
Cytoplasmic: 624-645

PTM

Cleaved by a furin endopeptidase in the trans-Golgi network.

Pietrzak, J., Szmajda-Krygier, D., Wosiak, A., Świechowski, R., Michalska, K., Mirowski, M., ... & Balcerczak, E. (2022). Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC). Biomedicine & Pharmacotherapy, 146, 112559.

Sugimoto, W., Itoh, K., Hirata, H., Abe, Y., Torii, T., Mitsui, Y., ... & Kawauchi, K. (2020). MMP24 as a target of YAP is a potential prognostic factor in cancer patients. Bioengineering, 7(1), 18.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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