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Rat Anti-MMP24 Recombinant Antibody (CBFYM-0403) (CBMAB-M0507-FY)

This product is rat antibody that recognizes MMP24. The antibody CBFYM-0403 can be used for immunoassay techniques such as: WB, FC, CyTOF.
See all MMP24 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0403
Antibody Isotype
IgG2
Application
WB, FC, CyTOF

Basic Information

Immunogen
Mouse MMP24
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MATRIX METALLOPEPTIDASE 24
Introduction
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2.
Entrez Gene ID
17391
UniProt ID
Q9R0S2
Alternative Names
Matrix Metallopeptidase 24; Matrix Metalloproteinase 24 (Membrane-Inserted); Matrix Metallopeptidase 24 (Membrane-Inserted); Membrane-Type 5 Matrix Metalloproteinase; Membrane-Type Matrix Metalloproteinase 5; MT-MMP 5; MT5-MMP; MMP-24; MT5MMP
Function
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
Biological Process
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Collagen catabolic process Source: GO_Central
Detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Glial cell differentiation Source: UniProtKB
Neuronal stem cell population maintenance Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Matrix metalloproteinase-24:
Plasma membrane
Cell membrane
Golgi apparatus
trans-Golgi network membrane
Note: Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3.
Processed matrix metalloproteinase-24:
Extracellular region or secreted
extracellular matrix
Note: Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.
Topology
Extracellular: 53-602
Helical: 603-623
Cytoplasmic: 624-645
PTM
Cleaved by a furin endopeptidase in the trans-Golgi network.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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