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Mouse Anti-MMP25 Recombinant Antibody (A1149) (CBMAB-AP4415LY)

The product is antibody recognizes MMP25. The antibody A1149 immunoassay techniques such as: ICC, IHC, IP, WB.
See all MMP25 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A1149
Antibody Isotype
IgG2b, κ
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Recombinant Matrix Metalloproteinase 25 (MMP25)
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Matrix Metallopeptidase 25
Introduction
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Entrez Gene ID
64386
UniProt ID
Q9NPA2
Alternative Names
Matrix Metallopeptidase 25; Membrane-Type Matrix Metalloproteinase 6; Matrix Metallopeptidase-Like 1; Leukolysin; MT-MMP 6; MT6-MMP; MMP-25; MT6MMP; MTMMP6; MMP20; MMPL1;
Function
May activate progelatinase A.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix organization Source: GO_Central
Hard palate development Source: Ensembl
Inflammatory response Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Extracellular region or secreted
extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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