MMP25

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Full Name
Matrix Metallopeptidase 25
Function
May activate progelatinase A.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix organization Source: GO_Central
Hard palate development Source: Ensembl
Inflammatory response Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Extracellular region or secreted
extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
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Anti-MMP25 antibodies

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Mouse Anti-MMP25 Recombinant Antibody (A1149) (CBMAB-AP4415LY)

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Target: MMP25
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A1149
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-MMP25 (AA 314-508) Recombinant Antibody (CBFYM-2395) (CBMAB-M2582-FY)

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Target: MMP25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2395
Application*: WB, IH
Datasheet SDS

Mouse Anti-MMP25 Recombinant Antibody (CBFYM-2394) (CBMAB-M2581-FY)

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Target: MMP25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2394
Application*: WB, P
Datasheet SDS

Mouse Anti-MMP25 Recombinant Antibody (CBFYM-0054) (CBMAB-M0060-FY)

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Target: MMP25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0054
Application*: F
Datasheet SDS

Human MMP25 ELISA Kit (V2LY-0626-LY4205)

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Target: MMP25
Sensitivity: 0.11 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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