Mouse Anti-MMRN1 Recombinant Antibody (V2-615616) (CBMAB-A5537-LY)

Name: Mouse Anti-MMRN1 Recombinant Antibody (V2-615616)
SKU: CBMAB-A5537-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-615616

Application

WB, ELISA

Immunogen

MMRN1 (NP_031377, 291 a.a. ~ 390 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

multimerin 1

Introduction

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq]

Entrez Gene ID

22915

UniProt ID

Q13201

Alternative Names

ECM; EMILIN4; GPIa*; MMRN

Function

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.

Biological Process

Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Cell adhesion mediated by integrin Source: ComplexPortal
Negative regulation of wound healing Source: ComplexPortal
Positive regulation of platelet aggregation Source: ComplexPortal

Cellular Location

Secreted

Involvement in disease

Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec).

PTM

The N-terminus is blocked.
Extensively N-glycosylated.

El Menshawy, N., El-Goneimy, M. S., Fathi, H., Saif, M., & Hashem, H. (2023). Implications of Multimerin-1 (MMRN-1) expression in adult de novo acute myeloid leukemia: a preliminary study in Delta Egypt. Egyptian Journal of Basic and Applied Sciences, 10(1), 671-681.

Yue, M., Hu, J., Min, X., & Xu, H. (2023). Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion. International Journal of Clinical and Experimental Pathology, 16(9), 252.

Zhou, Q., Liu, Y., & Zhang, W. (2023). Prognostic Value and Immunological Role of MMRN1: A Rising Star in Cancer.

Saini, A., Chandra, K. B., Kumar, V., Mathur, S. R., Sharma, J. B., Kumar, S., & Yadav, S. (2020). Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer. Molecular Biology Reports, 47, 9459-9468.

Leatherdale, A. (2020). The role of multimerin 1 (MMRN1) in platelet adhesion and characterization of its interactions with fibrillar collagens (Doctoral dissertation).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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