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MMRN1

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq]

Full Name

multimerin 1

Function

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.

Biological Process

Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Cell adhesion mediated by integrin Source: ComplexPortal
Negative regulation of wound healing Source: ComplexPortal
Positive regulation of platelet aggregation Source: ComplexPortal

Cellular Location

Secreted

Involvement in disease

Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec).

PTM

The N-terminus is blocked.
Extensively N-glycosylated.

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Anti-MMRN1 antibodies

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Mouse Mmrn1 ELISA Kit (V2LY-0626-LY2696)

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Target: Mmrn1

Sensitivity: 0.0052 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Mouse Anti-MMRN1 Recombinant Antibody (V2-615616) (CBMAB-A5537-LY)

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Target: MMRN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: V2-615616

Application*: WB, E

Mouse Anti-MMRN1 (AA 291-391) Recombinant Antibody (CBFYM-2430) (CBMAB-M2617-FY)

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Target: MMRN1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-2430

Application*: E, WB

Mouse Anti-MMRN1 Recombinant Antibody (CBFYE-1556) (CBMAB-E2204-FY)

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Target: MMRN1

Host: Mouse

Specificity: Human

Clone: CBFYE-1556

Application*: WB, IC, P, C, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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