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Mouse Anti-MNT Recombinant Antibody (CBFYM-2440) (CBMAB-M2627-FY)

This product is mouse antibody that recognizes MNT. The antibody CBFYM-2440 can be used for immunoassay techniques such as: Dot.
See all MNT antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYM-2440
Antibody Isotype
IgG1
Application
Dot

Basic Information

Immunogen
Raised against amino acids 226-361 of Mnt of human origin
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAX NETWORK TRANSCRIPTIONAL REPRESSOR
Introduction
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
Entrez Gene ID
4335
UniProt ID
Q99583
Alternative Names
MAX Network Transcriptional Repressor; Class D Basic Helix-Loop-Helix Protein 3; MNT, MAX Dimerization Protein; Max-Interacting Protein; MAX Binding Protein; Myc Antagonist MNT; BHLHd3
Function
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Biological Process
Cell aging Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of apoptotic signaling pathway Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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