Mouse Anti-MNT Recombinant Antibody (CBFYM-2442) (CBMAB-M2629-FY)

Name: Mouse Anti-MNT Recombinant Antibody (CBFYM-2442)
SKU: CBMAB-M2629-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2442

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Recombinant human MAX Binding Protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MAX NETWORK TRANSCRIPTIONAL REPRESSOR

Introduction

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

Entrez Gene ID

4335

UniProt ID

Q99583

Alternative Names

MAX Network Transcriptional Repressor; Class D Basic Helix-Loop-Helix Protein 3; MNT, MAX Dimerization Protein; Max-Interacting Protein; MAX Binding Protein; Myc Antagonist MNT; BHLHd3

Function

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Biological Process

Cell aging Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of apoptotic signaling pathway Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc

Cellular Location

Nucleus

More Infomation

References

Liaño-Pons, J., Arsenian-Henriksson, M., & León, J. (2021). The multiple faces of MNT and its role as a MYC modulator. Cancers, 13(18), 4682.

Lavin, D. P., Abassi, L., Inayatullah, M., & Tiwari, V. K. (2021). Mnt represses epithelial identity to promote epithelial-to-mesenchymal transition. Molecular and Cellular Biology, 41(11), e00183-21.

Lafita-Navarro, M. C., Liaño-Pons, J., Quintanilla, A., Varela, I., Blanco, R., Ourique, F., ... & León, J. (2020). The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells. Journal of Biological Chemistry, 295(7), 2001-2017.

Blaževitš, O., Bolshette, N., Vecchio, D., Guijarro, A., Croci, O., Campaner, S., & Grimaldi, B. (2019). MYC-associated factor MAX is an essential regulator of the clock core network. bioRxiv, 771329.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MNT Recombinant Antibody (CBFYM-2441)

Mouse Anti-MNT Recombinant Antibody (CBFYM-2440)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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