Mouse Anti-MOBP (AA 1-81) Recombinant Antibody (CBFYM-2459) (CBMAB-M2646-FY)

Name: Mouse Anti-MOBP (AA 1-81) Recombinant Antibody (CBFYM-2459)
SKU: CBMAB-M2646-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2459

Antibody Isotype

IgM, k

Application

ELISA, WB

Basic Information

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW ICCACQKTRL KRKIRPTPKK K

Specificity

Human

Antibody Isotype

IgM, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-81

Target

Full Name

myelin-associated oligodendrocyte basic protein

Introduction

MOBP is a Protein Coding gene. Diseases associated with MOBP include Substance Abuse and Multiple Sclerosis. Gene Ontology annotations related to this gene include Rab GTPase binding and structural constituent of myelin sheath. An important paralog of this gene is MYRIP.

Entrez Gene ID

4336

UniProt ID

Q13875

Alternative Names

Myelin-Associated Oligodendrocyte Basic Protein

Function

May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

Biological Process

Nervous system development Source: ProtInc

Cellular Location

Other locations
perinuclear region
Note: Present in the major dense line of CNS myelin.

More Infomation

References

Huang, C., Wu, Z., Wang, D., Qu, Y., Zhang, J., Jiang, R., ... & Yang, C. (2023). Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine. Molecular Psychiatry, 1-13.

Siokas, V., Aloizou, A. M., Liampas, I., Bakirtzis, C., Tsouris, Z., Sgantzos, M., ... & Dardiotis, E. (2022). Myelin‐associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease. Acta Neurologica Scandinavica, 145(2), 223-228.

Bettencourt, C., Miki, Y., Piras, I. S., de Silva, R., Foti, S. C., Talboom, J. S., ... & Holton, J. L. (2021). MOBP and HIP1 in multiple system atrophy: New α‐synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis. Neuropathology and applied neurobiology, 47(5), 640-652.

Kon, T., Tanji, K., Mori, F., Kimura, A., Kakita, A., & Wakabayashi, K. (2019). Immunoreactivity of myelin‐associated oligodendrocytic basic protein in Lewy bodies. Neuropathology, 39(4), 279-285.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MOBP Recombinant Antibody (4C2)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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