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Mouse Anti-MORC1 Recombinant Antibody (CBFYM-0706) (CBMAB-M0848-FY)

This product is mouse antibody that recognizes MORC1. The antibody CBFYM-0706 can be used for immunoassay techniques such as: ELISA, WB.
See all MORC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0706
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MORC family CW-type zinc finger 1
Introduction
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells.
Entrez Gene ID
27136
UniProt ID
Q86VD1
Alternative Names
MORC Family CW-Type Zinc Finger 1; Cancer/Testis Antigen 33; MORC; CT33; MORC Family CW-Type Zinc Finger Protein 1; Microrchidia, Mouse, Homolog Of; Microrchidia (Mouse) Homolog; Microrchidia Homolog (Mouse); ZCW6
Function
Required for spermatogenesis (By similarity).

Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).
Biological Process
Behavioral fear response Source: Ensembl
Cell differentiation Source: UniProtKB-KW
DNA hypermethylation Source: Ensembl
DNA methylation involved in gamete generation Source: Ensembl
Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of DNA-templated transcription, initiation Source: Ensembl
Negative regulation of transposition Source: Ensembl
Regulation of gene expression, epigenetic Source: Ensembl
Spermatogenesis Source: ProtInc
Cellular Location
Nucleus

Uneme, Y., Maeda, R., Nakayama, G., Narita, H., Takeda, N., Hiramatsu, R., ... & Yamanaka, S. (2023). Morc1 re-establishes heterochromatin on activated transposons and shapes the host transcriptome in gonocytes. bioRxiv, 2023-06.

Wang, C., Huang, J., Li, Y., Zhang, J., He, C., Li, T., ... & Wang, Y. (2022). DNA polymerase epsilon binds histone H3. 1-H4 and recruits MORC1 to mediate meiotic heterochromatin condensation. Proceedings of the National Academy of Sciences, 119(43), e2213540119.

Galli, M., Martiny, E., Imani, J., Kumar, N., Koch, A., Steinbrenner, J., & Kogel, K. H. (2022). CRISPR/Sp Cas9‐mediated double knockout of barley Microrchidia MORC1 and MORC6a reveals their strong involvement in plant immunity, transcriptional gene silencing and plant growth. Plant Biotechnology Journal, 20(1), 89-102.

Mundorf, A., Schmitz, J., Huenten, K., Fraenz, C., Schlueter, C., Genc, E., ... & Freund, N. (2021). MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex. Journal of Affective Disorders, 282, 91-97.

Mundorf, A., Koch, J., Kubitza, N., Wagner, S. C., Schmidt, M., Gass, P., & Freund, N. (2021). Morc1 as a potential new target gene in mood regulation: when and where to find in the brain. Experimental Brain Research, 239(10), 2999-3005.

Thomas, M., Coope, A., Falkenberg, C., Dunlop, B. W., Czamara, D., Provencal, N., ... & Nieratschker, V. (2020). Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms. Journal of psychiatric research, 120, 154-162.

Kim, H., Yen, L., Wongpalee, S. P., Kirshner, J. A., Mehta, N., Xue, Y., ... & Jacobsen, S. E. (2019). The gene-silencing protein MORC-1 topologically entraps DNA and forms multimeric assemblies to cause DNA compaction. Molecular cell, 75(4), 700-710.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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