MORC1

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq]

MORC family CW-type zinc finger 1

Required for spermatogenesis (By similarity).

Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).

Behavioral fear response Source: Ensembl
Cell differentiation Source: UniProtKB-KW
DNA hypermethylation Source: Ensembl
DNA methylation involved in gamete generation Source: Ensembl
Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of DNA-templated transcription, initiation Source: Ensembl
Negative regulation of transposition Source: Ensembl
Regulation of gene expression, epigenetic Source: Ensembl
Spermatogenesis Source: ProtInc

Nucleus