Rabbit Anti-MPC1 Recombinant Antibody (EG416) (CBMAB-EN474-LY)

The product is antibody recognizes MPC1 . The antibody EG416 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000.
See all MPC1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG416

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human BRP44L.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Mitochondrial Pyruvate Carrier 1

Introduction

The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]

Entrez Gene ID

Human	51660
Mouse	55951
Rat	171087

UniProt ID

Human	Q9Y5U8
Mouse	P63030
Rat	P63031

Alternative Names

Mitochondrial Pyruvate Carrier 1; Brain Protein 44-Like Protein; BRP44L; Brain Protein 44-Like; HSPC040 Protein; DJ68L15.3; CGI-129; SLC54A1; MPYCD;

Function

Mediates the uptake of pyruvate into mitochondria.

Biological Process

Mitochondrial pyruvate transmembrane transport Source: GO_Central

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Mitochondrial pyruvate carrier deficiency (MPYCD):
An autosomal recessive metabolic disorder characterized by severely delayed psychomotor development, mild dysmorphic features, hepatomegaly, marked metabolic acidosis, hyperlactacidemia with normal lactate/pyruvate, and encephalopathy. Some patients have epilepsy and peripheral neuropathy.

References

Liu, Y., Yuan, Y., Yan, Y., Wang, R., Wang, Z., Liu, X., ... & Zhao, L. (2023). Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats. Life Sciences, 325, 121686.

Jiang, H., Alahmad, A., Fu, S., Fu, X., Liu, Z., Han, X., ... & Fang, F. (2022). Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. Journal of Inherited Metabolic Disease, 45(2), 264-277.

Le, X. H., Lee, C. P., & Millar, A. H. (2021). The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism. The Plant Cell, 33(8), 2776-2793.

Xue, C., Li, G., Bao, Z., Zhou, Z., & Li, L. (2021). Mitochondrial pyruvate carrier 1: a novel prognostic biomarker that predicts favourable patient survival in cancer. Cancer Cell International, 21(1), 1-10.

Xu, L., Phelix, C. F., & Chen, L. Y. (2021). Structural insights into the human mitochondrial pyruvate carrier complexes. Journal of Chemical Information and Modeling, 61(11), 5614-5625.

Zangari, J., Petrelli, F., Maillot, B., & Martinou, J. C. (2020). The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier. Biomolecules, 10(7), 1068.

Tang, X. P., Chen, Q., Li, Y., Wang, Y., Zou, H. B., Fu, W. J., ... & Wu, X. F. (2019). Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma. Laboratory Investigation, 99(2), 191-199.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-MPC1 Recombinant Antibody (D2L9I)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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