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Mouse Anti-MPP2 (AA 1-552) Recombinant Antibody (CBFYM-2507) (CBMAB-M2694-FY)

This product is mouse antibody that recognizes MPP2. The antibody CBFYM-2507 can be used for immunoassay techniques such as: S-ELISA, IP, ELISA.
See all MPP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2507
Antibody Isotype
IgG1, k
Application
S-ELISA, IP, ELISA

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-552

Target

Full Name
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Introduction
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.
Entrez Gene ID
4355
UniProt ID
Q14168
Alternative Names
Membrane Palmitoylated Protein 2; Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2); MAGUK P55 Subfamily Member 2; Discs Large, Homolog 2; DLG2; Membrane Protein, Palmitoylated 2; Discs Large Homolog 2; Protein MPP2
Function
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity).

In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity).

Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).
Biological Process
Excitatory postsynaptic potential Source: UniProtKB
Long-term synaptic potentiation Source: UniProtKB
Protein homooligomerization Source: UniProtKB
Cellular Location
Cytoskeleton
Other locations
Membrane
dendrite
postsynaptic density
Note: Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.
PTM
Phosphorylated by SRC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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