Mouse Anti-MPP2 (AA 1-552) Recombinant Antibody (CBFYM-2507) (CBMAB-M2694-FY)

Name: Mouse Anti-MPP2 (AA 1-552) Recombinant Antibody (CBFYM-2507)
SKU: CBMAB-M2694-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2507

Application

S-ELISA, IP, ELISA

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-552

More Infomation

Target

Full Name

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

Introduction

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.

Entrez Gene ID

4355

UniProt ID

Q14168

Alternative Names

Membrane Palmitoylated Protein 2; Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2); MAGUK P55 Subfamily Member 2; Discs Large, Homolog 2; DLG2; Membrane Protein, Palmitoylated 2; Discs Large Homolog 2; Protein MPP2

Function

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity).

In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity).

Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).

Biological Process

Excitatory postsynaptic potential Source: UniProtKB
Long-term synaptic potentiation Source: UniProtKB
Protein homooligomerization Source: UniProtKB

Cellular Location

Cytoskeleton
Other locations
Membrane
dendrite
postsynaptic density
Note: Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.

PTM

Phosphorylated by SRC.

Yamada, T., Saitoh, Y., Kametani, K., Kamijo, A., Sakamoto, T., & Terada, N. (2022). Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus. Histochemistry and Cell Biology, 158(5), 497-511.

Peng, X. H., Chen, P. P., Zhang, Y., Wu, K., Ji, N., Gao, J. H., ... & Wang, H. (2021). MPP2 Interacts With SK2 Rescue The Excitability of Glutamatergic Neurons in The BLA and Facilitate The Extinction of Conditioned Fear in Mice.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MPP2 Recombinant Antibody (2B1) (CAT#: CBMAB-A5567-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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