MPP2

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq]

Full Name

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

Function

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity).

In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity).

Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).

Biological Process

Excitatory postsynaptic potential Source: UniProtKB
Long-term synaptic potentiation Source: UniProtKB
Protein homooligomerization Source: UniProtKB

Cellular Location

Cytoskeleton
Other locations
Membrane
dendrite
postsynaptic density
Note: Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.

PTM

Phosphorylated by SRC.