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Mouse Anti-MPPED2 Recombinant Antibody (4H5) (CBMAB-A5571-LY)

The product is antibody recognizes MPPED2. The antibody 4H5 immunoassay techniques such as: WB, ELISA.
See all MPPED2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MPPED2 (AAH31582, 1 a.a. ~ 294 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
metallophosphoesterase domain containing 2
Introduction
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq]
Entrez Gene ID
744
UniProt ID
Q15777
Alternative Names
239FB; C11orf8; D11S302E; FAM1B; Hs.46638; dJ1024C24.1; dJ873F21.1
Function
Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.

Sepe, R., Pellecchia, S., Serra, P., D’Angelo, D., Federico, A., Raia, M., ... & Pallante, P. (2023). Correction: Sepe et al. The Long Non-Coding RNA RP5-1024C24. 1 and Its Associated-Gene MPPED2 Are Down-Regulated in Human Thyroid Neoplasias and Act as Tumour Suppressors. Cancers 2018, 10, 146. Cancers, 15(15), 4003.

Zhong, Y., Wu, Y., Yang, Y., Chen, Y., Hui, R., Zhang, M., & Zhang, W. (2023). Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension. Journal of Human Genetics, 68(6), 393-398.

Gupta, K. (2021). Biochemical and functional characterization of the enigmatic MPPED1/MPPED2 metallophosphodiesterases (Doctoral dissertation).

Pellecchia, S., De Martino, M., Esposito, F., Quintavalle, C., Fusco, A., & Pallante, P. (2021). MPPED2 is downregulated in glioblastoma, and its restoration inhibits proliferation and increases the sensitivity to temozolomide of glioblastoma cells. Cell Cycle, 20(7), 716-729.

Katifelis, H., Sioziou, A., Gazouli, M., & Emmanouil, D. (2020). ACTN2 (rs6656267) and MPPED2 (rs11031093 and rs536007) polymorphisms in primary dentition caries: A case‐control study. International Journal of Paediatric Dentistry, 30(4), 478-482.

Schimunek, L., Namas, R. A., Yin, J., Barclay, D., Liu, D., El-Dehaibi, F., ... & Vodovotz, Y. (2019). MPPED2 polymorphism is associated with altered systemic inflammation and adverse trauma outcomes. Frontiers in genetics, 10, 1115.

Gu, S., Lin, S., Ye, D., Qian, S., Jiang, D., Zhang, X., ... & Chen, K. (2019). Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer. Clinical Epigenetics, 11(1), 1-12.

Pellecchia, S., Sepe, R., Federico, A., Cuomo, M., Credendino, S. C., Pisapia, P., ... & Pallante, P. (2019). The metallophosphoesterase-domain-containing protein 2 (MPPED2) gene acts as tumor suppressor in breast cancer. Cancers, 11(6), 797.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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