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Mouse Anti-MPPED2 (AA 1-295) Recombinant Antibody (CBFYM-2517) (CBMAB-M2704-FY)

This product is mouse antibody that recognizes MPPED2. The antibody CBFYM-2517 can be used for immunoassay techniques such as: WB.
See all MPPED2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2517
Antibody Isotype
IgM, k
Application
WB

Basic Information

Immunogen
Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgM, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-295

Target

Full Name
metallophosphoesterase domain containing 2
Introduction
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described.
Entrez Gene ID
UniProt ID
Alternative Names
Metallophosphoesterase Domain Containing 2; Metallophosphoesterase Domain-Containing Protein 2; Fetal Brain Protein 239; C11orf8; 239FB; Chromosome 11 Open Reading Frame 8; Metallophosphoesterase MPPED2; EC 3.1.-.-; FAM1B
Function
Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.

Sepe, R., Pellecchia, S., Serra, P., D’Angelo, D., Federico, A., Raia, M., ... & Pallante, P. (2023). Correction: Sepe et al. The Long Non-Coding RNA RP5-1024C24. 1 and Its Associated-Gene MPPED2 Are Down-Regulated in Human Thyroid Neoplasias and Act as Tumour Suppressors. Cancers 2018, 10, 146. Cancers, 15(15), 4003.

Zhong, Y., Wu, Y., Yang, Y., Chen, Y., Hui, R., Zhang, M., & Zhang, W. (2023). Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension. Journal of Human Genetics, 68(6), 393-398.

Gupta, K. (2021). Biochemical and functional characterization of the enigmatic MPPED1/MPPED2 metallophosphodiesterases (Doctoral dissertation).

Pellecchia, S., De Martino, M., Esposito, F., Quintavalle, C., Fusco, A., & Pallante, P. (2021). MPPED2 is downregulated in glioblastoma, and its restoration inhibits proliferation and increases the sensitivity to temozolomide of glioblastoma cells. Cell Cycle, 20(7), 716-729.

Katifelis, H., Sioziou, A., Gazouli, M., & Emmanouil, D. (2020). ACTN2 (rs6656267) and MPPED2 (rs11031093 and rs536007) polymorphisms in primary dentition caries: A case‐control study. International Journal of Paediatric Dentistry, 30(4), 478-482.

Schimunek, L., Namas, R. A., Yin, J., Barclay, D., Liu, D., El-Dehaibi, F., ... & Vodovotz, Y. (2019). MPPED2 polymorphism is associated with altered systemic inflammation and adverse trauma outcomes. Frontiers in genetics, 10, 1115.

Gu, S., Lin, S., Ye, D., Qian, S., Jiang, D., Zhang, X., ... & Chen, K. (2019). Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer. Clinical Epigenetics, 11(1), 1-12.

Pellecchia, S., Sepe, R., Federico, A., Cuomo, M., Credendino, S. C., Pisapia, P., ... & Pallante, P. (2019). The metallophosphoesterase-domain-containing protein 2 (MPPED2) gene acts as tumor suppressor in breast cancer. Cancers, 11(6), 797.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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