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Rabbit Anti-MPRIP Recombinant Antibody (D9I5T) (CBMAB-CP2274-LY)

The product is antibody recognizes MPRIP. The antibody D9I5T immunoassay techniques such as: WB.
See all MPRIP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D9I5T
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro165 of human M-RIP protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myosin Phosphatase Rho Interacting Protein
Introduction
MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.
Entrez Gene ID
23164
UniProt ID
Q6WCQ1
Alternative Names
Myosin Phosphatase Rho Interacting Protein; Rho Interacting Protein 3; P116Rip; RHOIP3; M-RIP; MRIP;
Function
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Biological Process
Actin filament organization Source: GO_Central
Cellular Location
Cytoskeleton
Note: Colocalizes with F-actin.

Choi, H., Nguyen, H. N., & Lamb, F. (2023). LRRC8A Anion Channel Associates with Myosin Phosphatase Rho Interacting Protein (MPRIP) to Regulate Vascular Function. Physiology, 38(S1), 5732946.

Balaban, C., Sztacho, M., Antiga, L., Miladinović, A., Harata, M., & Hozák, P. (2023). PIP2-Effector protein MPRIP regulates RNA polymerase II condensation and transcription. Biomolecules, 13(3), 426.

Choi, H., Miller, M. R., Hong-Ngan, N., Rohrbough, J. C., Koch, S. R., Boatwright, N., ... & Lamb, F. S. (2023). LRRC8A anion channels modulate vascular reactivity via association with Myosin Phosphatase Rho Interacting Protein (MPRIP). FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 37(7), e23028.

Wang, D., Gu, L., Zheng, J., Zhang, Q., Xu, Q., Li, R., ... & Gu, M. (2023). Germline VWF/MPRIP and somatoplasm FGA variants synergically confer susceptibility to non-traumatic osteonecrosis of the femoral head. Scientific Reports, 13(1), 3112.

Choi, H., Miller, M. R., Nguyen, H. N., Rohrbough, J. C., Koch, S. R., Boatwright, N., ... & Lamb, F. S. (2023). LRRC8A anion channels modulate vasodilation via association with Myosin Phosphatase Rho Interacting Protein (MPRIP). bioRxiv, 2023-03.

Balaban, C., Sztacho, M., Blažíková, M., & Hozák, P. (2021). The F-actin-binding MPRIP forms phase-separated condensates and associates with PI (4, 5) P2 and active RNA polymerase II in the cell nucleus. Cells, 10(4), 848.

Shu, Y., Li, H., Shang, H., Chen, J., Su, X., Le, W., ... & Wu, W. (2020). Identification of a novel MPRIP-ROS1 fusion and clinical efficacy of crizotinib in an advanced lung adenocarcinoma patient: a case report. OncoTargets and therapy, 10387-10391.

Fang, W., Gan, J., Lu, F., Deng, Y., Chen, L., Yang, Y., & Zhang, L. (2019). MPRIP-ALK, a novel ALK rearrangement that responds to ALK inhibitor in non-small-cell lung cancer. Cancer Research, 79(13_Supplement), 3460-3460.

Fang, W., Gan, J., Hong, S., Lu, F., & Zhang, L. (2019). MPRIP-ALK, a novel ALK rearrangement that responds to alk inhibition in NSCLC. Journal of Thoracic Oncology, 14(7), e148-e151.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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