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Mouse Anti-MPST Recombinant Antibody (1B5) (CBMAB-1605-CN)

This product is a mouse antibody that recognizes MPST of human. The antibody 1B5 can be used for immunoassay techniques such as: ELISA, IP.
See all MPST antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG1, Κ
Application
ELISA, IP

Basic Information

Immunogen
MPST (NP_001013454.1, aa. 1-100) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, Κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
mercaptopyruvate sulfurtransferase
Introduction
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. This protein acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells.
Entrez Gene ID
4357
UniProt ID
P25325
Alternative Names
MST; TST2; TUM1
Function
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H2S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.
Biological Process
Cyanate catabolic process Source: ProtInc
Hydrogen sulfide biosynthetic process Source: UniProtKB
Kidney development Source: Ensembl
Liver development Source: Ensembl
Response to toxic substance Source: ProtInc
Spinal cord development Source: Ensembl
Sulfur amino acid catabolic process Source: Reactome
Transsulfuration Source: GO_Central
Cellular Location
Mitochondrion
Cytoplasm By similarity
Other locations
synaptosome
Involvement in disease
Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4973015, PubMed:4690911 and PubMed:6945862). Some cases have associated mental retardation (PubMed:4973015 and PubMed:6945862).

Pedre, B., Talwar, D., Barayeu, U., Schilling, D., Luzarowski, M., Sokolowski, M., ... & Dick, T. P. (2023). 3-Mercaptopyruvate sulfur transferase is a protein persulfidase. Nature Chemical Biology, 19(4), 507-517.

Nagahara, N., & Ito, T. (2023). 3-Mercaptopyruvate sulfurtransferase: the molecular and functional properties. In Sulfurtransferases (pp. 1-53). Academic Press.

Pedre, B., & Dick, T. P. (2021). 3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking. Biological chemistry, 402(3), 223-237.

Augsburger, F., Randi, E. B., Jendly, M., Ascencao, K., Dilek, N., & Szabo, C. (2020). Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation, migration, and bioenergetics in murine colon cancer cells. Biomolecules, 10(3), 447.

Yadav, P. K., Vitvitsky, V., Carballal, S., Seravalli, J., & Banerjee, R. (2020). Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations. Journal of Biological Chemistry, 295(19), 6299-6311.

Augsburger, F., & Szabo, C. (2020). Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells. Pharmacological research, 154, 104083.

Akahoshi, N., Minakawa, T., Miyashita, M., Sugiyama, U., Saito, C., Takemoto, R., ... & Ishii, I. (2020). Increased urinary 3-mercaptolactate excretion and enhanced passive systemic anaphylaxis in mice lacking mercaptopyruvate sulfurtransferase, a model of mercaptolactate-cysteine disulfiduria. International Journal of Molecular Sciences, 21(3), 818.

Hipólito, A., Nunes, S. C., Vicente, J. B., & Serpa, J. (2020). Cysteine aminotransferase (CAT): a pivotal sponsor in metabolic remodeling and an ally of 3-mercaptopyruvate sulfurtransferase (MST) in cancer. Molecules, 25(17), 3984.

Panagaki, T., Randi, E. B., & Szabo, C. (2020). Role of hydrogen sulfide and 3-mercaptopyruvate sulfurtransferase in the regulation of the endoplasmic reticulum stress response in hepatocytes. Biomolecules, 10(12), 1692.

Nagahara, N., Tanaka, M., Tanaka, Y., & Ito, T. (2019). Novel characterization of antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice: overexpression of the evolutionarily-related enzyme rhodanese. Antioxidants, 8(5), 116.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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