Mouse Anti-MRAP Recombinant Antibody (CBXF-2426) (CBMAB-F1851-CQ)

Name: Mouse Anti-MRAP Recombinant Antibody (CBXF-2426)
SKU: CBMAB-F1851-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2426

Application

ELISA, WB, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MELANOCORTIN 2 RECEPTOR ACCESSORY PROTEIN

Introduction

This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described.

Entrez Gene ID

56246

UniProt ID

Q8TCY5

Alternative Names

Melanocortin 2 Receptor Accessory Protein; Fat Cell-Specific Low Molecular Weight Protein; Fat Tissue-Specific Low MW Protein; C21orf61; FALP; B27;

Function

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

Biological Process

Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Negative regulation of protein localization to plasma membrane Source: BHF-UCL
Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Protein localization to plasma membrane Source: BHF-UCL
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Plasma membrane
Cell membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.

Involvement in disease

Glucocorticoid deficiency 2 (GCCD2):
A form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.

Topology

Helical: 38-58

Ji, R. L., Jiang, S. S., & Tao, Y. X. (2022). Modulation of Canine Melanocortin-3 and-4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2. Biomolecules, 12(11), 1608.

Wang, X., Xue, S., Lei, X., Song, W., Li, L., Li, X., ... & Guo, J. (2022). Pharmacological evaluation of melanocortin 2 receptor accessory protein 2 on axolotl neural melanocortin signaling. Frontiers in Endocrinology, 13, 820896.

Ji, R. L., & Tao, Y. X. (2022). Regulation of melanocortin-3 and-4 receptors by isoforms of melanocortin-2 receptor accessory protein 1 and 2. Biomolecules, 12(2), 244.

Fullone, M. R., Maftei, D., Vincenzi, M., Lattanzi, R., & Miele, R. (2022). Identification of regions involved in the physical interaction between melanocortin receptor accessory protein 2 and prokineticin receptor 2. Biomolecules, 12(3), 474.

Dores, R. M., & Chapa, E. (2021). Hypothesis and Theory: Evaluating the co-evolution of the melanocortin-2 receptor and the accessory protein MRAP1. Frontiers in Endocrinology, 12, 747843.

Berruien, N. N., & Smith, C. L. (2020). Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. Gene, 757, 144949.

Chen, V., Bruno, A. E., Britt, L. L., Hernandez, C. C., Gimenez, L. E., Peisley, A., ... & Millhauser, G. L. (2020). Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2. Journal of Biological Chemistry, 295(48), 16370-16379.

Soletto, L., Hernández-Balfagó, S., Rocha, A., Scheerer, P., Kleinau, G., & Cerdá-Reverter, J. M. (2019). Melanocortin receptor accessory protein 2-induced adrenocorticotropic hormone response of human melanocortin 4 receptor. Journal of the Endocrine Society, 3(2), 314-323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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