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Mouse Anti-MRAP Recombinant Antibody (CBXF-2426) (CBMAB-F1851-CQ)

This product is a mouse antibody that recognizes MRAP. The antibody CBXF-2426 can be used for immunoassay techniques such as: ELISA, WB, IHC-P.
See all MRAP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2426
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MELANOCORTIN 2 RECEPTOR ACCESSORY PROTEIN
Introduction
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described.
Entrez Gene ID
56246
UniProt ID
Q8TCY5
Alternative Names
Melanocortin 2 Receptor Accessory Protein; Fat Cell-Specific Low Molecular Weight Protein; Fat Tissue-Specific Low MW Protein; C21orf61; FALP; B27;
Function
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Biological Process
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Negative regulation of protein localization to plasma membrane Source: BHF-UCL
Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Protein localization to plasma membrane Source: BHF-UCL
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cellular Location
Plasma membrane
Cell membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.
Involvement in disease
Glucocorticoid deficiency 2 (GCCD2):
A form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.
Topology
Helical: 38-58

Ji, R. L., Jiang, S. S., & Tao, Y. X. (2022). Modulation of Canine Melanocortin-3 and-4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2. Biomolecules, 12(11), 1608.

Wang, X., Xue, S., Lei, X., Song, W., Li, L., Li, X., ... & Guo, J. (2022). Pharmacological evaluation of melanocortin 2 receptor accessory protein 2 on axolotl neural melanocortin signaling. Frontiers in Endocrinology, 13, 820896.

Ji, R. L., & Tao, Y. X. (2022). Regulation of melanocortin-3 and-4 receptors by isoforms of melanocortin-2 receptor accessory protein 1 and 2. Biomolecules, 12(2), 244.

Fullone, M. R., Maftei, D., Vincenzi, M., Lattanzi, R., & Miele, R. (2022). Identification of regions involved in the physical interaction between melanocortin receptor accessory protein 2 and prokineticin receptor 2. Biomolecules, 12(3), 474.

Dores, R. M., & Chapa, E. (2021). Hypothesis and Theory: Evaluating the co-evolution of the melanocortin-2 receptor and the accessory protein MRAP1. Frontiers in Endocrinology, 12, 747843.

Berruien, N. N., & Smith, C. L. (2020). Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. Gene, 757, 144949.

Chen, V., Bruno, A. E., Britt, L. L., Hernandez, C. C., Gimenez, L. E., Peisley, A., ... & Millhauser, G. L. (2020). Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2. Journal of Biological Chemistry, 295(48), 16370-16379.

Soletto, L., Hernández-Balfagó, S., Rocha, A., Scheerer, P., Kleinau, G., & Cerdá-Reverter, J. M. (2019). Melanocortin receptor accessory protein 2-induced adrenocorticotropic hormone response of human melanocortin 4 receptor. Journal of the Endocrine Society, 3(2), 314-323.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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