Mouse Anti-MRC1 Recombinant Antibody (CBT2533) (V2LY-0625-LY1663)

Name: Mouse Anti-MRC1 Recombinant Antibody (CBT2533)
SKU: V2LY-0625-LY1663
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-MRC1 Recombinant Antibody (CBT2533) (V2LY-0625-LY1663) in WB

Mouse Anti-MRC1 Recombinant Antibody (CBT2533) (V2LY-0625-LY1663) in FC

Mouse Anti-MRC1 Recombinant Antibody (CBT2533) (V2LY-0625-LY1663) in IF

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2533

Antibody Isotype

IgG1

Application

ICC, FC

Basic Information

Immunogen

Purified recombinant fragment of human CD206 (AA: extra(19-218)) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
FC	1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Mannose Receptor C-Type 1

Entrez Gene ID

4360

UniProt ID

P22897

Function

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein.

Biological Process

Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Endosome
Endosome membrane

Topology

Extracellular: 19-1389
Helical: 1390-1410
Cytoplasmic: 1411-1456

More Infomation

References

Rahabi, M., Jacquemin, G., Prat, M., Meunier, E., AlaEddine, M., Bertrand, B., ... & Coste, A. (2020). Divergent roles for macrophage C-type lectin receptors, dectin-1 and mannose receptors, in the intestinal inflammatory response. Cell Reports, 30(13), 4386-4398.

Kovacs, L., Cabral, P., & Chammas, R. (2020). Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations. Plos one, 15(10), e0240455.

Subramanian, K., Neill, D. R., Malak, H. A., Spelmink, L., Khandaker, S., Dalla Libera Marchiori, G., ... & Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature microbiology, 4(1), 62-70.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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