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MRC1

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Full Name
Mannose Receptor C-Type 1
Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Biological Process
Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Endosome
Endosome membrane
Topology
Extracellular: 19-1389
Helical: 1390-1410
Cytoplasmic: 1411-1456

Anti-MRC1 antibodies

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Mouse Anti-MRC1 Recombinant Antibody (CBWJC-2330) (CBMAB-C3255WJ)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2330
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (CBXC-2424) (CBMAB-C4680-CQ)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2424
Application*: F, IP, WB, C, IC, FN

Mouse Anti-MRC1 Recombinant Antibody (CBFYC-0299) (CBMAB-C0332-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0299
Application*: F

Mouse Anti-MRC1 Antibody (MR Mab #46) (CBMAB-0075-YC)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MR Mab #46
Application*: E, FP, B, IF, IH, WB

Mouse Anti-MRC1 (AA 22-131) Recombinant Antibody (CBFYM-2533) (CBMAB-M2720-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2533
Application*: E, P, WB

Rat Anti-MRC1 (AA 19-1383) Recombinant Antibody (CBFYM-2532) (CBMAB-M2719-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2532
Application*: IC

Mouse Anti-MRC1 (AA 19-1383) Recombinant Antibody (CBFYM-2531) (CBMAB-M2718-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2531
Application*: IH, WB

Rat Anti-MRC1 Recombinant Antibody (CBWJC-4163) (CBMAB-C5507WJ)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-4163
Application*: IS, F

Rat Anti-MRC1 Recombinant Antibody (CBFYM-0022) (CBMAB-M0026-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0022
Application*: F, IF, IH, IP, WB

Mouse Anti-MRC1 (AA 19-1383) Recombinant Antibody (CBFYM-0044) (CBMAB-M0050-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0044
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0058) (CBMAB-M0066-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0058
Application*: C, FN, WB

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0059) (CBMAB-M0067-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0059
Application*: F, IA, C, WB

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0146) (CBMAB-M0167-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Horse, Human
Clone: CBFYM-0146
Application*: WB, C, F, I, IH, IF

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0195) (CBMAB-M0231-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0195
Application*: F, IH, WB

Rat Anti-MRC1 (AA 19-1388) Recombinant Antibody (CBFYM-0216) (CBMAB-M0259-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0216
Application*: F

Rabbit Anti-MRC1 Recombinant Antibody (CBFYM-0314) (CBMAB-M0379-FY)

Datasheet SDS
Target: MRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0314
Application*: WB, IF

Rat Anti-MRC1 Recombinant Antibody (CBFYM-0370) (CBMAB-M0457-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0370
Application*: C, F, IF, IP

Rat Anti-MRC1 Recombinant Antibody (CBFYM-0472) (CBMAB-M0595-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0472
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0474) (CBMAB-M0601-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0474
Application*: E, F, C, IP, WB

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0715) (CBMAB-M0857-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0715
Application*: IH

Rat Anti-MRC1 Recombinant Antibody (CBFYM-0716) (CBMAB-M0858-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0716
Application*: IF, IH, IP, WB

Mouse Anti-MRC1 Recombinant Antibody (CBFYA-0095) (CBMAB-X0138-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0095
Application*: F, C, FN, WB

Rat Anti-MRC1 Recombinant Antibody (CBFYA-0020) (CBMAB-X0035-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0020
Application*: FC, IF, IHC, ICC

Rat Anti-MRC1 Recombinant Antibody (CBFYM-2537) (CBMAB-M2724-FY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-2537
Application*: F, IF, IH, IP, WB

Mouse Anti-MRC1 Recombinant Antibody (CBFYM-2535) (CBMAB-M2722-FY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Sheep
Clone: CBFYM-2535
Application*: F, IH, IP, P, C

Mouse Anti-MRC1 Recombinant Antibody (85) (CBMAB-AP3009LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 85
Application*: ELISA, WB

Mouse Anti-MRC1 Recombinant Antibody (15-2) (CBMAB-C0351-LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 15-2
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (3H1994) (CBMAB-C6271-LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1994
Application*: F, IF, C, WB

Mouse Anti-MRC1 Recombinant Antibody (7-450) (CBMAB-C8497-LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7-450
Application*: C

Mouse Anti-MRC1 Recombinant Antibody (685641) (CBMAB-C1532-YY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 685641
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (CBYY-C2670) (CBMAB-C4111-YY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2670
Application*: F, IF, IH, WB

Rabbit Anti-MRC1 Recombinant Antibody (7H24) (CBMAB-C3950-CN)

Datasheet SDS
Target: MRC1
Host: Rabbit
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H24
Application*: E, IF

Rat Anti-MRC1 Recombinant Antibody (MR5D3) (CBMAB-C12061-LY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MR5D3
Application*: F

Rat Anti-MRC1 Recombinant Antibody (MR6F3) (CBMAB-C12062-LY)

Datasheet SDS
Target: MRC1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: MR6F3
Application*: F

Mouse Anti-MRC1 Recombinant Antibody (5C11) (CBMAB-A5576-LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5C11
Application*: WB, E

Rabbit Anti-MRC1 Recombinant Antibody (E2L9N) (CBMAB-CP1577-LY)

Datasheet SDS
Target: MRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E2L9N
Application*: WB, IH, P

Mouse Anti-MRC1 Recombinant Antibody (CB313) (CBMAB-CS313LY)

Datasheet SDS
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB313
Application*: IF, FC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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