MRC1
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Full Name
Mannose Receptor C-Type 1
Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Biological Process
Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Endosome
Endosome membrane
Cell membrane
Endosome
Endosome membrane
Topology
Extracellular: 19-1389
Helical: 1390-1410
Cytoplasmic: 1411-1456
Helical: 1390-1410
Cytoplasmic: 1411-1456
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Anti-MRC1 antibodies
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CompareTarget: MRC1
Host: Rabbit
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H24
Application*: E, IF
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MR Mab #46
Application*: E, FP, B, IF, IH, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-4163
Application*: IS, F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2330
Application*: F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2424
Application*: F, IP, WB, C, IC, FN
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 685641
Application*: F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0299
Application*: F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2533
Application*: IC, F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3398
Application*: IH, F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 85
Application*: ELISA, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB313
Application*: IF, FC
Target: MRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E2L9N
Application*: WB, IH, P
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5C11
Application*: WB, E
Target: MRC1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: MR6F3
Application*: F
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MR5D3
Application*: F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0095
Application*: F, C, FN, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0020
Application*: FC, IF, IHC, ICC
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2670
Application*: F, IF, IH, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-2537
Application*: F, IF, IH, IP, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Sheep
Clone: CBFYM-2535
Application*: F, IH, IP, P, C
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2533
Application*: E, P, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2532
Application*: IC
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2531
Application*: IH, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0716
Application*: IF, IH, IP, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0715
Application*: IH
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0474
Application*: E, F, C, IP, WB
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0472
Application*: F
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0370
Application*: C, F, IF, IP
Target: MRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0314
Application*: WB, IF
Target: MRC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0216
Application*: F
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0195
Application*: F, IH, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Horse, Human
Clone: CBFYM-0146
Application*: WB, C, F, I, IH, IF
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0059
Application*: F, IA, C, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0058
Application*: C, FN, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0044
Application*: F
Target: MRC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0022
Application*: F, IF, IH, IP, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7-450
Application*: C
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1994
Application*: F, IF, C, WB
Target: MRC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 15-2
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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