Rat Anti-MRC1 Recombinant Antibody (CBFYM-0716) (CBMAB-M0858-FY)

Name: Rat Anti-MRC1 Recombinant Antibody (CBFYM-0716)
SKU: CBMAB-M0858-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-0716

Application

IF, IHC, IP, WB

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mannose Receptor C-Type 1

Introduction

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Entrez Gene ID

17533

UniProt ID

Q61830

Alternative Names

Mannose Receptor C-Type 1; Macrophage Mannose Receptor 1-Like Protein 1; C-Type Lectin Domain Family 13 Member D; Mannose Receptor, C Type 1-Like 1; Human Mannose Receptor; CLEC13DL; CLEC13D; MRC1L1; MMR

Function

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein.

Biological Process

Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Endosome
Endosome membrane

Topology

Extracellular: 19-1389
Helical: 1390-1410
Cytoplasmic: 1411-1456

Rahabi, M., Jacquemin, G., Prat, M., Meunier, E., AlaEddine, M., Bertrand, B., ... & Coste, A. (2020). Divergent roles for macrophage C-type lectin receptors, dectin-1 and mannose receptors, in the intestinal inflammatory response. Cell Reports, 30(13), 4386-4398.

Kovacs, L., Cabral, P., & Chammas, R. (2020). Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations. Plos one, 15(10), e0240455.

Subramanian, K., Neill, D. R., Malak, H. A., Spelmink, L., Khandaker, S., Dalla Libera Marchiori, G., ... & Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature microbiology, 4(1), 62-70.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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