Mouse Anti-MRC2 Recombinant Antibody (CBFYM-0717) (CBMAB-M0859-FY)

Name: Mouse Anti-MRC2 Recombinant Antibody (CBFYM-0717)
SKU: CBMAB-M0859-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0717

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

mannose receptor, C type 2

Introduction

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

Entrez Gene ID

9902

UniProt ID

Q9UBG0

Alternative Names

Mannose Receptor C Type 2; C-Type Lectin Domain Family 13 Member E; Endocytic Receptor 180; Urokinase-Type Plasminogen Activator Receptor-Associated Protein; Macrophage Mannose Receptor 2; UPAR-Associated Protein; CLEC13E; ENDO180; UPARAP

Function

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Biological Process

Collagen catabolic process Source: UniProtKB
Endocytosis Source: UniProtKB-KW
Osteoblast differentiation Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 31-1414
Helical: 1415-1435
Cytoplasmic: 1436-1479

PTM

N-glycosylated.

vinayakam Gopalakrishnan, K., Kannan, B., Pandi, C., Jayaseelan, V. P., & Arumugam, P. (2023). Prognostic and clinicopathological significance of MRC2 expression in head and neck squamous cell carcinoma. Journal of Stomatology, Oral and Maxillofacial Surgery, 124(6), 101617.

Zhao, Z., Yang, Y., Liu, Z., Chen, H., Guan, X., Jiang, Z., ... & Wang, X. (2022). Prognostic and immunotherapeutic significance of mannose receptor C type II in 33 cancers: An integrated analysis. Frontiers in Molecular Biosciences, 9, 951636.

Arnone, M., Görsch, E., Pöschel, S., Stanger, A., Rudat, S., & Lengerke, C. (2022). The Role of Mannose Receptor C-Type 2 (MRC2) in Leukemic Stem Cell Maintenance in AML. Blood, 140(Supplement 1), 8706-8706.

Li, L., Chen, X., Zhang, H., Wang, M., & Lu, W. (2021). MRC2 promotes proliferation and inhibits apoptosis of diabetic nephropathy. Analytical Cellular Pathology, 2021, 1-10.

Dong, Y., Yang, L., Luo, W., Zhu, T., Yan, W., Kong, J., ... & Zhao, Q. (2019). Mannose receptor C type 2 mediates 1, 25 (OH) 2D3/vitamin D receptor-regulated collagen metabolism through collagen type 5, alpha 2 chain and matrix metalloproteinase 13 in murine MC3T3-E1 cells. Molecular and cellular endocrinology, 483, 74-86.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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