Mouse Anti-MRM2 Recombinant Antibody (2372C6a) (CBMAB-F2515-CQ)

Name: Mouse Anti-MRM2 Recombinant Antibody (2372C6a)
SKU: CBMAB-F2515-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2372C6a

Application

Dot, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mitochondrial RRNA Methyltransferase 2

Introduction

The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair.

Entrez Gene ID

29960

UniProt ID

Q9UI43

Alternative Names

Mitochondrial RRNA Methyltransferase 2; 16S RRNA (Uridine(1369)-2-O)-Methyltransferase; 16S RRNA [Um1369] 2-O-Methyltransferase; RRNA (Uridine-2-O-)-Methyltransferase; Protein FtsJ Homolog 2; FTSJ2; FJH1; MRM2 RNA Methyltransferase Homolog (S. Cerevisiae); FtsJ RNA Methyltransferase Homolog 2 (E. Coli); Putative Ribosomal RNA Methyltransferase 2;

Function

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Biological Process

RNA methylation Source: GO_Central
rRNA 2'-O-methylation Source: Reactome
rRNA methylation Source: BHF-UCL
rRNA processing Source: BHF-UCL

Cellular Location

Mitochondrion

Involvement in disease

Mitochondrial DNA depletion syndrome 17 (MTDPS17):
An autosomal recessive mitochondrial disorder characterized by childhood onset of rapidly progressive encephalopathy, stroke-like episodes, lactic acidosis, hypocitrullinemia, multiple defects of oxidative phosphorylation, mitochondrial complex I and IV deficiency, and reduced mtDNA copy number.

Rebelo-Guiomar, P., Pellegrino, S., Dent, K. C., Sas-Chen, A., Miller-Fleming, L., Garone, C., ... & Minczuk, M. (2022). A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit. Nature communications, 13(1), 929.

Wang, P., Li, J., Wu, M., Ye, M., Huang, K., & Zhu, X. (2021). Human Mitochondrial Ribosomal RNA Modification-Based Classification Contributes to Discriminate the Prognosis and Immunotherapy Response of Glioma Patients. Frontiers in Immunology, 12, 722479.

Lopez Sanchez, M. I. G., Cipullo, M., Gopalakrishna, S., Khawaja, A., & Rorbach, J. (2020). Methylation of ribosomal RNA: a mitochondrial perspective. Frontiers in Genetics, 11, 761.

Laptev, I., Shvetsova, E., Levitskii, S., Serebryakova, M., Rubtsova, M., Bogdanov, A., ... & Dontsova, O. (2020). Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA. RNA biology, 17(4), 441-450.

Chen, H., Shi, Z., Guo, J., Chang, K. J., Chen, Q., Yao, C. H., ... & Shi, Y. (2020). The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function. Journal of Biological Chemistry, 295(25), 8505-8513.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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