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Mouse Anti-MRM2 Recombinant Antibody (CBXF-1010) (CBMAB-F2516-CQ)

This product is a mouse antibody that recognizes MRM2. The antibody CBXF-1010 can be used for immunoassay techniques such as: WB.
See all MRM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1010
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitochondrial RRNA Methyltransferase 2
Introduction
The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair.
Entrez Gene ID
UniProt ID
Alternative Names
Mitochondrial RRNA Methyltransferase 2; 16S RRNA (Uridine(1369)-2-O)-Methyltransferase; 16S RRNA [Um1369] 2-O-Methyltransferase; RRNA (Uridine-2-O-)-Methyltransferase; Protein FtsJ Homolog 2; FTSJ2; FJH1; MRM2 RNA Methyltransferase Homolog (S. Cerevisiae); FtsJ RNA Methyltransferase Homolog 2 (E. Coli); Putative Ribosomal RNA Methyltransferase 2;
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Biological Process
RNA methylation Source: GO_Central
rRNA 2'-O-methylation Source: Reactome
rRNA methylation Source: BHF-UCL
rRNA processing Source: BHF-UCL
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrial DNA depletion syndrome 17 (MTDPS17):
An autosomal recessive mitochondrial disorder characterized by childhood onset of rapidly progressive encephalopathy, stroke-like episodes, lactic acidosis, hypocitrullinemia, multiple defects of oxidative phosphorylation, mitochondrial complex I and IV deficiency, and reduced mtDNA copy number.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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