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Mouse Anti-MRPL12 (AA 1-199) Recombinant Antibody (CBFYM-2553) (CBMAB-M2740-FY)

This product is mouse antibody that recognizes MRPL12. The antibody CBFYM-2553 can be used for immunoassay techniques such as: IF, WB.
See all MRPL12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2553
Antibody Isotype
IgG1, k
Application
IF, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-199

Target

Full Name
mitochondrial ribosomal protein L12
Introduction
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.
Entrez Gene ID
6182
UniProt ID
P52815
Alternative Names
Mitochondrial Ribosomal Protein L12; Mitochondrial Large Ribosomal Subunit Protein BL12m; MRP-L12; RPML12; 5c5-2; L12mt
Function
As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation (PubMed:23603806).

Associates with mitochondrial RNA polymerase to activate transcription.
Biological Process
Mitochondrial transcription Source: HGNC-UCL
Mitochondrial translation Source: ComplexPortal
Positive regulation of transcription, DNA-templated Source: HGNC-UCL
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 45 (COXPD45):
An autosomal recessive mitochondrial disorder with onset in utero and characterized by poor overall growth, failure to thrive, global developmental delay, poor or absent speech, seizures, hypotonia, loss of walking, acute progressive neurologic deterioration, brain lesions, and facial dysmorphism. Laboratory studies show increased serum lactate and decreased mitochondrial respiratory chain enzyme activity in patient tissues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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