Mouse Anti-MRPL44 Recombinant Antibody (CBFYM-2564) (CBMAB-M2752-FY)

Name: Mouse Anti-MRPL44 Recombinant Antibody (CBFYM-2564)
SKU: CBMAB-M2752-FY
Rating: 5 (1 reviews)

See all MRPL44 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2564

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN L44

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Entrez Gene ID

65080

UniProt ID

Q9H9J2

Alternative Names

Mitochondrial Ribosomal Protein L44; Mitochondrial Large Ribosomal Subunit Protein ML44; 39S Ribosomal Protein L44, Mitochondrial; MRP-L44; L44MT; EC 3.1.26.-; EC 3.1.26; COXPD16

Function

Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.

Biological Process

Mitochondrial translation Source: ComplexPortal
Mitochondrial translational elongation Source: UniProtKB
RNA processing Source: InterPro
rRNA catabolic process Source: InterPro

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 16 (COXPD16):
An autosomal recessive, mitochondrial disorder characterized by hypertrophic cardiomyopathy, liver steatosis, and decreased levels of mitochondrial complexes I and IV in heart and skeletal muscle.

Horga, A., Manole, A., Mitchell, A. L., Bugiardini, E., Hargreaves, I. P., Mowafi, W., ... & Houlden, H. (2021). Uniparental isodisomy of chromosome 2 causing MRPL44-related multisystem mitochondrial disease. Molecular Biology Reports, 48, 2093-2104.

Friederich, M. W., Geddes, G. C., Wortmann, S. B., Punnoose, A., Wartchow, E., Knight, K. M., ... & Van Hove, J. L. (2021). Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Molecular genetics and metabolism, 133(4), 362-371.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MRPL44 Recombinant Antibody (CBFYM-2564)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry