Human Recombinant MRPL44 protein, His Tag (V2LY-0526-LY5637)

Name: Human Recombinant MRPL44 protein, His Tag
SKU: V2LY-0526-LY5637
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant MRPL44 protein, His Tag consist of Amino Acid: 1-332 and predicts a molecular mass of 35.7 kDa.

Molecule Mass

35.7 kDa

Sequence

Amino Acid: 1-332

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol, Trehalose

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN L44

Function

Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.

Biological Process

Mitochondrial translation Source: ComplexPortal
Mitochondrial translational elongation Source: UniProtKB
RNA processing Source: InterPro
rRNA catabolic process Source: InterPro

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 16 (COXPD16):
An autosomal recessive, mitochondrial disorder characterized by hypertrophic cardiomyopathy, liver steatosis, and decreased levels of mitochondrial complexes I and IV in heart and skeletal muscle.

Horga, A., Manole, A., Mitchell, A. L., Bugiardini, E., Hargreaves, I. P., Mowafi, W., ... & Houlden, H. (2021). Uniparental isodisomy of chromosome 2 causing MRPL44-related multisystem mitochondrial disease. Molecular Biology Reports, 48, 2093-2104.

Friederich, M. W., Geddes, G. C., Wortmann, S. B., Punnoose, A., Wartchow, E., Knight, K. M., ... & Van Hove, J. L. (2021). Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Molecular genetics and metabolism, 133(4), 362-371.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MRPL44 Recombinant Antibody (CBFYM-2564) (CAT#: CBMAB-M2752-FY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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