Mouse Anti-MRPS27 Recombinant Antibody (1G3) (CBMAB-A5590-LY)

Name: Mouse Anti-MRPS27 Recombinant Antibody (1G3)
SKU: CBMAB-A5590-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1G3

Application

sELISA, ELISA

Immunogen

MRPS27 (AAH30521, 51 a.a. ~ 168 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Mitochondrial Ribosomal Protein S27

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). [provided by RefSeq]

Entrez Gene ID

23107

UniProt ID

Q92552

Alternative Names

FLJ21764; FLJ23348; KIAA0264; MRP-S27; S27mt

Function

RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715).

Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715).

Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715).

Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366).

Biological Process

Cell population proliferation Source: UniProtKB
Mitochondrial translation Source: ComplexPortal
Positive regulation of mitochondrial translation Source: UniProtKB

Cellular Location

Cytoplasm
Mitochondrion

Zhao, M., Liu, A., Mo, L., Wan, G., & Lu, F. (2023). The value of RPS15 and MRPS27 in ischemic stroke. Medicine, 102(33), e34706.

Zhang, T., Qin, Z., Liu, D., Wei, M., Fu, Z., Wang, Q., ... & Zhang, Z. (2021). A novel transcription factor MRPS27 up-regulates the expression of sqr, a key gene of mitochondrial sulfide metabolism in echiuran worm Urechis unicinctus. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 243, 108997.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MRPS27 Matched Antibody Pair (751) (CAT#: APMAB-751LY)

Related Products

Mouse Anti-MRPS27 (AA 151-414) Recombinant Antibody (CBFYM-2581) (CAT#: CBMAB-M2769-FY)

MRPS27 Matched Antibody Pair (751) (CAT#: APMAB-751LY)

Mouse Anti-MRPS27 (AA 51-168) Recombinant Antibody (CBFYM-2580) (CAT#: CBMAB-M2768-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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