Rabbit Anti-MS4A1 Recombinant Antibody (RM272) (CBMAB-C4341-CQ)

Name: Rabbit Anti-MS4A1 Recombinant Antibody (RM272)
SKU: CBMAB-C4341-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

RM272

Application

WB, IHC

Immunogen

A peptide corresponding to the C-terminus of human CD20

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Membrane Spanning 4-Domains A1

Introduction

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Entrez Gene ID

931

UniProt ID

P11836

Alternative Names

Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1;

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111).

Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).

Biological Process

B cell activation Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Calcium ion import into cytosol Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Humoral immune response Source: UniProtKB
Protein tetramerization Source: UniProtKB
Response to bacterium Source: Ensembl
Store-operated calcium entry Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Note: Constitutively associated with membrane rafts.

Involvement in disease

Immunodeficiency, common variable, 5 (CVID5):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Topology

Cytoplasmic: 1-56
Helical: 57-78
Extracellular: 79-84
Helical: 85-105
Cytoplasmic: 106-120
Helical: 121-141
Extracellular: 142-188
Helical: 189-209
Cytoplasmic: 210-297

PTM

Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.

Xuan, Z., Liu, L., Zhang, G., Zheng, X., Jiang, J., Wang, K., & Huang, P. (2023). Novel cell subtypes of SPP1+ S100P+, MS4A1-SPP1+ S100P+ were key subpopulations in intrahepatic cholangiocarcinoma. Biochimica et Biophysica Acta (BBA)-General Subjects, 1867(9), 130420.

Song, Y., Zhang, Z., Zhang, B., & Zhang, W. (2022). CD8+ T cell-associated genes MS4A1 and TNFRSF17 are prognostic markers and inhibit the progression of colon cancer. Frontiers in Oncology, 12, 941208.

Li, S., & Fang, Y. (2022). MS4A1 as a potential independent prognostic factor of breast cancer related to lipid metabolism and immune microenvironment based on TCGA database analysis. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 28, e934597-1.

Mudd Jr, T. W., Lu, C., Klement, J. D., & Liu, K. (2021). MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment. Cellular immunology, 360, 104260.

Jiang, D., Mo, Q., Sun, X., Wang, X., Dong, M., Zhang, G., ... & Zhao, Q. (2021). Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20. Cancer Science, 112(9), 3585-3597.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MS4A1 Matched Antibody Pair (753) (CAT#: APMAB-753LY)

MS4A1 Matched Antibody Pair (754) (CAT#: APMAB-754LY)

MS4A1 Matched Antibody Pair (755) (CAT#: APMAB-755LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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