MS4A1
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Full Name
Membrane Spanning 4-Domains A1
Alternative Names
Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1;
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111).
Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Biological Process
B cell activation Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Calcium ion import into cytosol Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Humoral immune response Source: UniProtKB
Protein tetramerization Source: UniProtKB
Response to bacterium Source: Ensembl
Store-operated calcium entry Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Calcium ion import into cytosol Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Humoral immune response Source: UniProtKB
Protein tetramerization Source: UniProtKB
Response to bacterium Source: Ensembl
Store-operated calcium entry Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Note: Constitutively associated with membrane rafts.
Cell membrane
Note: Constitutively associated with membrane rafts.
Involvement in disease
Immunodeficiency, common variable, 5 (CVID5):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Cytoplasmic: 1-56
Helical: 57-78
Extracellular: 79-84
Helical: 85-105
Cytoplasmic: 106-120
Helical: 121-141
Extracellular: 142-188
Helical: 189-209
Cytoplasmic: 210-297
Helical: 57-78
Extracellular: 79-84
Helical: 85-105
Cytoplasmic: 106-120
Helical: 121-141
Extracellular: 142-188
Helical: 189-209
Cytoplasmic: 210-297
PTM
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
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Anti-MS4A1 antibodies
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CompareTarget: MS4A1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: QCH6A7
Application*: F
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BV11
Application*: IH, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B16
Application*: FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: CBWJC-2331
Application*: F, IH
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM272
Application*: WB, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AG140
Application*: MC, F, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF070
Application*: ELISA, WB, IHC, FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig
Clone: MEM-97
Application*: IP, F
Target: MS4A1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: SA271G2
Application*: F
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-020
Application*: E
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5B15
Application*: E, F, IF, IH, IP
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1A3
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT285
Application*: P, IF, IC, E
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT286
Application*: P, IF
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT623
Application*: WB, P, IF, E
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT2184
Application*: IH, IC
Target: MS4A1
Specificity: Human
Target: MS4A1
Specificity: Human
Target: MS4A1
Specificity: Human
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A1181
Application*: IHC, IP, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A1180
Application*: ELISA, IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A1179
Application*: FC
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CAP949
Application*: IHC, WB
Target: MS4A1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F381
Application*: FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PT0029
Application*: IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 103
Application*: ELISA, IHC, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP947
Application*: IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PDR78
Application*: FC, IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB363A
Application*: ELISA, IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB99A
Application*: ELISA, IHC
Target: MS4A1
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: HI47
Application*: FC
Target: MS4A1
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: HI20a
Application*: ELISA, FC, IHC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HI20a
Application*: FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB318
Application*: IF, FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB317
Application*: IF, FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB316
Application*: IF, FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB315
Application*: IF, FC
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB314
Application*: IF, FC
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb170
Application*: WB, IH
Target: MS4A1
Host: Mouse
Specificity: Human
Clone: IHC532
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C1-H8
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: MEM-269
Application*: F
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: RMC20-1
Application*: P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: rIGEL/773
Application*: P, IF/IC, C
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP32
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM494
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: HI47
Application*: E, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CAT13.6E12
Application*: IH, FC
Target: MS4A1
Host: Human
Specificity: Human
Clone: 9j116
Application*: E
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: 3H1089
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G76
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13B120
Application*: E, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 9A138
Application*: FC, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Baboon, Monkey
Clone: L26 + IGEL/733
Application*: F, IF, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4176
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4175
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4174
Application*: F, Neat
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E17-P
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4173
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4171
Application*: WB, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4169
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-4168
Application*: F, IF, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4167
Application*: C
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4166
Application*: C, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT80
Application*: IP, F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: HI47
Application*: B, E, F, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2335
Application*: E, F, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2334
Application*: F, P, C
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBWJC-2333
Application*: WB, P, F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2332
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: B-H20
Application*: F, FN
Target: MS4A1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AISB12
Application*: F, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PDR78
Application*: F, IH
Target: MS4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: IGEL/1497R
Application*: F, IF, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: NKI-B20
Application*: E, F, C, IP
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1889
Application*: P, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2630
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2629
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2335
Application*: WB, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: B342
Application*: F, IF, IH, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXC-2342
Application*: F, IH, IP
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM618
Application*: F, IF, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: L26
Application*: C, P
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-Ly1
Application*: F, IP
Target: MS4A1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0875
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LT20
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2676
Application*: IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2675
Application*: IH, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Rat
Clone: CBYY-C2674
Application*: F, IC, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: CBYY-C2673
Application*: E, IH, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2672
Application*: WB, IH
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C1241
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1240
Application*: E, WB
Target: MS4A1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBYY-C1238
Application*: E, F, IF, IH, IP
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1237
Application*: E, P, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1235
Application*: IH, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1234
Application*: F, IP
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1233
Application*: P, WB
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: CBYY-C0740
Application*: F
Target: MS4A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 93-1B3
Application*: F, IF
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* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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