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Mouse Anti-MS4A2 (AA 1-59) Recombinant Antibody (CBFYM-2608) (CBMAB-M2796-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2608
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQE
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-59

Target

Full Name
Membrane Spanning 4-Domains A2
Introduction
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Entrez Gene ID
2206
UniProt ID
Q01362
Alternative Names
Membrane Spanning 4-Domains A2; Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide; Membrane-Spanning 4-Domains Subfamily A Member 2; IgE Fc Receptor Subunit Beta; FCER1B; FcERI; IGER; APY; High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain); Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide); High Affinity Immunoglobulin Epsilon Receptor Subunit Beta
Function
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Fc-epsilon receptor signaling pathway Source: InterPro
Immune response Source: UniProtKB
Inflammatory response Source: InterPro
Cellular Location
Membrane
Topology
Cytoplasmic: 1-59
Helical: 60-79
Extracellular: 80-97
Helical: 98-117
Cytoplasmic: 118-130
Helical: 131-150
Extracellular: 151-180
Helical: 181-200
Cytoplasmic: 201-244
PTM
Phosphorylated on tyrosine residues by LYN.
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For research use only. Not intended for any clinical use.

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