Mouse Anti-MS4A2 (AA 1-59) Recombinant Antibody (CBFYM-2608) (CBMAB-M2796-FY)

Name: Mouse Anti-MS4A2 (AA 1-59) Recombinant Antibody (CBFYM-2608)
SKU: CBMAB-M2796-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2608

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQE

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-59

More Infomation

Target

Full Name

Membrane Spanning 4-Domains A2

Introduction

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.

Entrez Gene ID

2206

UniProt ID

Q01362

Alternative Names

Membrane Spanning 4-Domains A2; Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide; Membrane-Spanning 4-Domains Subfamily A Member 2; IgE Fc Receptor Subunit Beta; FCER1B; FcERI; IGER; APY; High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain); Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide); High Affinity Immunoglobulin Epsilon Receptor Subunit Beta

Function

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Fc-epsilon receptor signaling pathway Source: InterPro
Immune response Source: UniProtKB
Inflammatory response Source: InterPro

Cellular Location

Membrane

Topology

Cytoplasmic: 1-59
Helical: 60-79
Extracellular: 80-97
Helical: 98-117
Cytoplasmic: 118-130
Helical: 131-150
Extracellular: 151-180
Helical: 181-200
Cytoplasmic: 201-244

PTM

Phosphorylated on tyrosine residues by LYN.

Hua, L., Chen, Q., Liu, Q. H., Guo, Y. F., Cheng, R. H., Zhang, J., ... & Ji, R. X. (2021). Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study. BMC pediatrics, 21, 1-6.

Al Abdulsalam, E. A., Al-Hajjaj, M. S., Alanazi, M. S., & Warsy, A. S. (2020). Lack of Association Between Interleukin 13, Interleukin 4 Receptor Alpha, and MS4A2 gene polymorphisms and asthma in adult Saudis. Journal of Nature and Science of Medicine, 3(3), 196-203.

Ohmori, S. Y., Ishijima, Y., Numata, S., Takahashi, M., Sekita, M., Sato, T., ... & Ohneda, K. (2019). GATA2 and PU. 1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRI β, through Distinct Mechanisms. Molecular and cellular biology, 39(22), e00314-19.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

MS4A2 Matched Antibody Pair (756) (CAT#: APMAB-756LY)

Related Products

MS4A2 Matched Antibody Pair (756) (CAT#: APMAB-756LY)

Mouse Anti-MS4A2 Recombinant Antibody (CBXF-1839) (CAT#: CBMAB-F3374-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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