Mouse Anti-MS4A3 Recombinant Antibody (CBFYM-0159) (CBMAB-M0180-FY)

This product is mouse antibody that recognizes MS4A3. The antibody CBFYM-0159 can be used for immunoassay techniques such as: FC.
See all MS4A3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0159

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

NS0 mouse myeloma cell line transfected with human MS4A3

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MEMBRANE SPANNING 4-DOMAINS A3

Introduction

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.

Entrez Gene ID

932

UniProt ID

Q96HJ5

Alternative Names

Membrane Spanning 4-Domains A3; Membrane-Spanning 4-Domains, Subfamily A, Member 3 (Hematopoietic Cell-Specific); Hematopoietic-Specific Transmembrane Protein 4; CD20 Antigen-Like Protein; CD20L.htm4

Function

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Regulation of cell cycle Source: InterPro

Cellular Location

Endomembrane system
perinuclear region
Note: Located in the perinuclear area.

Topology

Cytoplasmic: 1-49
Helical: 50-70
Extracellular: 71-81
Helical: 82-102
Cytoplasmic: 103-124
Helical: 125-145
Extracellular: 146-175
Helical: 176-196
Cytoplasmic: 197-214

References

Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J., Hwang, J. Y., ... & Deininger, M. W. (2022). MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis. Blood, The Journal of the American Society of Hematology, 139(5), 761-778.

Xu, L., Wei, W., Qian, J., Zhang, S., Jin, Z., Wang, X., ... & Wang, J. (2022). Short-term intensive fasting improves red blood cell function and rejuvenates erythropoiesis via regulating MS4A3-CDK2 module. medRxiv, 2022-08.

Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J., Hwang, J. Y., ... & Deininger, M. W. (2021). MS4A3 Promotes Differentiation in Chronic Myeloid Leukemia By Enhancing Common β Chain Cytokine Receptor Endocytosis. Blood, 138, 59.

Lu, Q., Guo, P., Wang, X., Ares, I., Lopez-Torres, B., Martínez-Larrañaga, M. R., ... & Martínez, M. A. (2021). MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biology and Toxicology, 1-16.

Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., ... & Ginhoux, F. (2019). Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Cell, 178(6), 1509-1525.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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