MS4A3

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.

Full Name

MEMBRANE SPANNING 4-DOMAINS A3

Function

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Regulation of cell cycle Source: InterPro

Cellular Location

Endomembrane system
perinuclear region
Note: Located in the perinuclear area.

Topology

Cytoplasmic: 1-49
Helical: 50-70
Extracellular: 71-81
Helical: 82-102
Cytoplasmic: 103-124
Helical: 125-145
Extracellular: 146-175
Helical: 176-196
Cytoplasmic: 197-214