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Mouse Anti-MSMB Recombinant Antibody (CBFYM-0737) (CBMAB-M0879-FY)

This product is mouse antibody that recognizes MSMB. The antibody CBFYM-0737 can be used for immunoassay techniques such as: ELISA, WB.
See all MSMB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0737
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
microseminoprotein, beta-
Introduction
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.
Entrez Gene ID
4477
UniProt ID
P08118
Alternative Names
Microseminoprotein Beta; Prostate Secretory Protein Of 94 Amino Acids; Prostate Secreted Seminal Plasma Protein; Seminal Plasma Beta-Inhibin; Beta-Microseminoprotein; PSP-94; PSP94; IGBF; PN44; Immunoglobulin Binding Factor
Cellular Location
Secreted
Note: Sperm surface.
Involvement in disease
Prostate cancer, hereditary, 13 (HPC13):
A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

Darayee, M., Geramizadeh, B., Tabei, S. M. B., Rezvani, A., Soleimanian, S., & Rahimi, A. (2022). Suggesting Tissue-Specific MSMB Gene Promoter as a Novel Approach for Prostate Targeted Gene Therapy. Asian Pacific Journal of Cancer Prevention: APJCP, 23(6), 1993.

Coste, F., Moreau, T., Labas, V., Chessé, M., Bregeon, M., Meudal, H., ... & Réhault‐Godbert, S. (2021). Three‐dimensional structures of avian beta‐microseminoproteins: insight from the chicken egg‐specific beta‐microseminoprotein 3 paralog. FEBS Open bio, 11(6), 1739-1756.

Wang, C., Qi, X., Zhou, X., Sun, J., Cai, D., Lu, G., ... & Zhao, H. (2020). RNA‐Seq analysis on ets1 mutant embryos of Xenopus tropicalis identifies microseminoprotein beta gene 3 as an essential regulator of neural crest migration. The FASEB Journal, 34(9), 12726-12738.

Shrivastava, P., Garg, H., Bhat, M., Dinda, A., & Kumar, R. (2020). Urinary prostate-specific antigen and microseminoprotein-beta levels in men with and without prostate cancer: A prospective cohort study. Indian Journal of Urology: IJU: Journal of the Urological Society of India, 36(1), 50.

Tumova, L., Zigo, M., Sutovsky, P., Sedmikova, M., & Postlerova, P. (2020). The ubiquitin-proteasome system does not regulate the degradation of porcine β-microseminoprotein during sperm capacitation. International Journal of Molecular Sciences, 21(11), 4151.

Bicak, M., Wang, X., Gao, X., Xu, X., Väänänen, R. M., Taimen, P., ... & Klein, R. J. (2020). Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB. Human molecular genetics, 29(10), 1581-1591.

Byrne, K. S., Appleby, P. N., Key, T. J., Holmes, M. V., Fensom, G. K., Agudo, A., ... & PRACTICAL Consortium. (2019). The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case–control and Mendelian randomization study in the European prospective investigation into cancer and nutrition. Annals of Oncology, 30(6), 983-989.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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