Mouse Anti-MSR1 Recombinant Antibody (CBWJC-4178) (CBMAB-C5526WJ)

Name: Mouse Anti-MSR1 Recombinant Antibody (CBWJC-4178)
SKU: CBMAB-C5526WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-4178

Application

IHC-P

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Macrophage Scavenger Receptor 1

Introduction

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4481

UniProt ID

P21757

Alternative Names

Macrophage Scavenger Receptor 1; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; SCARA1; Macrophage Scavenger Receptor Types I And II; Macrophage Scavenger Receptor Type III; CD204 Antigen; SR-AIII;

Function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254).

Isoform III does not internalize acetylated LDL (PubMed:9548586).

Biological Process

Amyloid-beta clearance Source: ARUK-UCL
Cellular response to organic cyclic compound Source: Ensembl
Cholesterol transport Source: BHF-UCL
Lipoprotein transport Source: Ensembl
Negative regulation of gene expression Source: ARUK-UCL
Phagocytosis, engulfment Source: ARUK-UCL
Plasma lipoprotein particle clearance Source: BHF-UCL
Positive regulation of cholesterol storage Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Cellular Location

Membrane

Involvement in disease

Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Topology

Cytoplasmic: 1-50
Helical: 51-76
Extracellular: 77-451

Onyishi, C. U., Desanti, G. E., Wilkinson, A. L., Lara-Reyna, S., Frickel, E. M., Fejer, G., ... & May, R. C. (2023). Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen. Nature Communications, 14(1), 4895.

Baos, S., Cremades-Jimeno, L., López-Ramos, M., de Pedro, M. Á., Uriarte, S. A., Sastre, J., ... & Cárdaba, B. (2022). Expression of macrophage scavenger receptor (MSR1) in peripheral blood cells from patients with different respiratory diseases: Beyond monocytes. Journal of Clinical Medicine, 11(5), 1439.

Gudgeon, J., Marín-Rubio, J. L., & Trost, M. (2022). The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Frontiers in Immunology, 13, 1012002.

Govaere, O., Petersen, S. K., Martinez-Lopez, N., Wouters, J., Van Haele, M., Mancina, R. M., ... & Härtlova, A. (2022). Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. Journal of hepatology, 76(5), 1001-1012.

Sheng, W., Ji, G., & Zhang, L. (2022). Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. Frontiers in Immunology, 13, 1050984.

Li, B., Chen, M., Aguzzi, A., & Zhu, C. (2021). The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine, 99, 877-887.

Zheng, M., Tian, T., Liang, J., Ye, S., Chen, J., & Ji, Y. (2021). High-expressed macrophage scavenger receptor 1 predicts severity clinical outcome in transplant patient in idiopathic pulmonary fibrosis disease. Journal of Immunology Research, 2021.

Yang, L., Geng, T., Yang, G., Ma, J., Wang, L., Ketkar, H., ... & Wang, P. (2020). Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology, 3(1), 556.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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For research use only. Not intended for any clinical use.

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