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Mouse Anti-MSRB1 Recombinant Antibody (CBXS-5921) (CBMAB-S0770-CQ)

This product is a mouse antibody that recognizes MSRB1. The antibody CBXS-5921 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all MSRB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5921
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Methionine Sulfoxide Reductase B1
Introduction
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19.
Entrez Gene ID
51734
UniProt ID
Q9NZV6
Alternative Names
Methionine Sulfoxide Reductase B1; Selenoprotein X, 1; Selenoprotein R; SEPX1; SELX; Methionine-R-Sulfoxide Reductase B1; Selenoprotein X;
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Biological Process
Actin filament polymerization Source: UniProtKB
Innate immune response Source: UniProtKB
Protein repair Source: HGNC-UCL
Cellular Location
Nucleus
Cytoskeleton
Cytoplasm
PTM
Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component).

Tarrago, L., Kaya, A., Kim, H. Y., Manta, B., Lee, B. C., & Gladyshev, V. N. (2022). The selenoprotein methionine sulfoxide reductase B1 (MSRB1). Free Radical Biology and Medicine.

Yoo, H. J., Choi, D. W., Roh, Y. J., Lee, Y. M., Lim, J. H., Eo, S., ... & Kim, J. H. (2022). MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation. Cell Reports, 41(6).

Chen, X. Y., Yang, S. Y., Ruan, X. J., Ding, H. Y., Wang, N. X., Liu, F., ... & Li, Y. (2021). MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3β/β-catenin Signaling Axis. Cell transplantation, 30, 09636897211053203.

Shi, T., Song, J., You, G., Yang, Y., Liu, Q., & Li, N. (2021). The function of selenium in central nervous system: lessons from MsrB1 knockout mouse models. Molecules, 26(5), 1372.

Wojciechowska, N., Bagniewska-Zadworna, A., Minicka, J., Michalak, K. M., & Kalemba, E. M. (2021). Localization and dynamics of the methionine sulfoxide reductases msrb1 and msrb2 in beech seeds. International Journal of Molecular Sciences, 22(1), 402.

Lee, H. J., Park, J. S., Yoo, H. J., Lee, H. M., Lee, B. C., & Kim, J. H. (2020). The selenoprotein MsrB1 instructs dendritic cells to induce T-helper 1 immune responses. Antioxidants, 9(10), 1021.

Stolarska, E., Bilska, K., Wojciechowska, N., Bagniewska-Zadworna, A., Rey, P., & Kalemba, E. M. (2020). Integration of MsrB1 and MsrB2 in the redox network during the development of orthodox and recalcitrant Acer seeds. Antioxidants, 9(12), 1250.

Shi, T., Yang, Y., Zhang, Z., Zhang, L., Song, J., Ping, Y., ... & Li, N. (2019). Loss of MsrB1 perturbs spatial learning and long-term potentiation/long-term depression in mice. Neurobiology of Learning and Memory, 166, 107104.

Jia, Y., Dai, J., Zhang, L., & Xia, H. (2019). Effect of exogenous zinc on MsrB1 expression and protein oxidation in human lens epithelial cells. Biological Trace Element Research, 190, 60-64.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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