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Mouse Anti-MT1 Recombinant Antibody (CBFYM-2702) (CBMAB-M2892-FY)

This product is mouse antibody that recognizes MT1. The antibody CBFYM-2702 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all MT1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYM-2702
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Specificity
Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
metallothionein 1
Introduction
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Entrez Gene ID
24567
UniProt ID
P02803
Alternative Names
Mt; Mt1a
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Biological Process
Cellular metal ion homeostasis Source: RGD
Cellular response to cadmium ion Source: RGD
Cellular response to chromate Source: RGD
Cellular response to copper ion Source: GO_Central
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: RGD
Detoxification of copper ion Source: RGD
Negative regulation of growth Source: UniProtKB
Negative regulation of neuron apoptotic process Source: RGD
Nitric oxide mediated signal transduction Source: RGD
Response to cadmium ion Source: RGD
Response to zinc ion Source: RGD
Cellular Location
Cytosol
Lysosome
Nucleus
Other locations
cytoplasm

Ma, Y., Du, J., Yin, Z., Dai, H., Wei, Y., Xia, Y., ... & Huang, Z. (2023). Metallothionein-1 is Positively Correlated with Inflammation and Ankylosing Spondylitis Activity. Journal of Inflammation Research, 5935-5944.

Ma, Y., Yin, Z., Dai, H., Wu, D., Cong, J., Huang, X., ... & Huang, Z. (2023). Increased metallothionein-1 associated with gout activity and tophi. Immunological Investigations, 52(3), 319-331.

Dai, H., Wang, L., Li, L., Huang, Z., & Ye, L. (2021). Metallothionein 1: A new spotlight on inflammatory diseases. Frontiers in Immunology, 12, 739918.

Ogushi, S., Yoshida, Y., Nakanishi, T., & Kimura, T. (2020). CpG site-specific regulation of metallothionein-1 gene expression. International Journal of Molecular Sciences, 21(17), 5946.

Lorenzo-Gutiérrez, D., Gómez-Gil, L., Guarro, J., Roncero, M. I. G., Fernández-Bravo, A., Capilla, J., & López-Fernández, L. (2019). Role of the Fusarium oxysporum metallothionein Mt1 in resistance to metal toxicity and virulence. Metallomics, 11(7), 1230-1240.

Bensellam, M., Shi, Y. C., Chan, J. Y., Laybutt, D. R., Chae, H., Abou-Samra, M., ... & Jonas, J. C. (2019). Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans. Diabetologia, 62, 2273-2286.

McNeill, R. V., Mason, A. S., Hodson, M. E., Catto, J. W., & Southgate, J. (2019). Specificity of the metallothionein-1 response by cadmium-exposed normal human urothelial cells. International Journal of Molecular Sciences, 20(6), 1344.

Wang, C., Gong, Z., Hu, S., & Zhang, G. (2019). Metallothionein-1 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells. International Immunopharmacology, 75, 105815.

Ljubojević, M., Orct, T., Micek, V., Karaica, D., Jurasović, J., Breljak, D., ... & Sabolić, I. (2019). Sex-dependent expression of metallothioneins MT1 and MT2 and concentrations of trace elements in rat liver and kidney tissues: Effect of gonadectomy. Journal of Trace Elements in Medicine and Biology, 53, 98-108.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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