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Mouse Anti-MTA2 Recombinant Antibody (A1196) (CBMAB-AP12302LY)

The product is antibody recognizes MTA2. The antibody A1196 immunoassay techniques such as: ELISA, IF, IHC, WB.
See all MTA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
A1196
Antibody Isotype
IgG2b
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of MTA2
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Metastasis Associated 1 Family Member 2
Introduction
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Entrez Gene ID
Human9219
Mouse23942
UniProt ID
HumanO94776
MouseQ9R190
Alternative Names
Metastasis Associated 1 Family Member 2; Metastasis Associated Gene Family, Member 2; P53 Target Protein In Deacetylase Complex; Metastasis-Associated 1-Like 1; MTA1-L1 Protein; MTA1L1;
Function
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Biological Process
Chromatin assembly or disassembly Source: ProtInc
Chromatin remodeling Source: ComplexPortal
DNA methylation Source: Ensembl
Histone deacetylation Source: ComplexPortal
Negative regulation of transcription, DNA-templated Source: ComplexPortal
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell fate specification Source: ComplexPortal
Regulation of fibroblast migration Source: Ensembl
Regulation of stem cell differentiation Source: ComplexPortal
Cellular Location
Nucleus

Li, A., Guo, Y., Yin, Z., Liu, X., & Xie, G. (2023). MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5. Journal of Cancer, 14(2), 262.

Dai, S. L., Wei, S. S., Zhang, C., Li, X. Y., Liu, Y. P., Ma, M., ... & Shan, B. E. (2021). MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E‐Twist feedback loop. Cancer Science, 112(3), 1060-1074.

Lin, C. L., Ying, T. H., Yang, S. F., Chiou, H. L., Chen, Y. S., Kao, S. H., & Hsieh, Y. H. (2021). MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis. Cell Death & Disease, 12(5), 451.

Tao, D., Zhang, Z., Liu, X., Zhang, Z., Fu, Y., Zhang, P., ... & Jiang, H. (2020). LncRNA HOTAIR promotes the invasion and metastasis of oral squamous cell carcinoma through metastasis‐associated gene 2. Molecular Carcinogenesis, 59(4), 353-364.

El-Nikhely, N., Karger, A., Sarode, P., Singh, I., Weigert, A., Wietelmann, A., ... & Savai, R. (2020). Metastasis-associated protein 2 represses NF-κB to reduce lung tumor growth and inflammation. Cancer Research, 80(19), 4199-4211.

Chen, Y. S., Hung, T. W., Su, S. C., Lin, C. L., Yang, S. F., Lee, C. C., ... & Tsai, J. P. (2019). MTA2 as a potential biomarker and its involvement in metastatic progression of human renal cancer by miR-133b targeting MMP-9. Cancers, 11(12), 1851.

Hsu, W. H., Chiou, H. L., Lin, C. L., Kao, S. H., Lee, H. L., Liu, C. J., & Hsieh, Y. H. (2019). Metastasis-associated protein 2 regulates human hepatocellular carcinoma metastasis progression through modulating p38MAPK/MMP2 pathways. Journal of Cancer, 10(26), 6716.

Tseng, T. Y., Chiou, H. L., Lin, C. W., Chen, Y. S., Hsu, L. S., Lee, C. H., & Hsieh, Y. H. (2019). Repression of metastasis‐associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p‐cofilin‐1/LC3‐II expression. Journal of Oral Pathology & Medicine, 48(10), 959-966.

Guan, C., Chang, Z., Gu, X., & Liu, R. (2019). MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway. Biochemical and biophysical research communications, 515(1), 112-118.

Si, W., Liu, X., Wei, R., Zhang, Y., Zhao, Y., Cui, L., & Hong, T. (2019). MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. Cell Death & Disease, 10(3), 206.

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For research use only. Not intended for any clinical use.

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