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Mouse Anti-MTA2 (AA 2-276) Recombinant Antibody (CBFYM-2714) (CBMAB-M2906-FY)

This product is mouse antibody that recognizes MTA2. The antibody CBFYM-2714 can be used for immunoassay techniques such as: WB, IP, ELISA, IF.
See all MTA2 antibodies
Published Data
Fig.1 Cytoskeletal changes associated with MTA2 overexpression and ROCK inhibition.
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Fig.2 MTA2 immunofluorescence staining in HBECs treated with DMSO or 0.1 μm BaP for 12 h.
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Fig.3 Western blot for MTA3 and RT‐PCR analysis of MTA2/3 in HBECs treated with scrambled siRNA or siRNA against MTA1/2/3. Similar results were seen in three independent experiments using triplicates in each of these experiments.
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Fig.4 The relative expression level of MTA2 was determined in human lung adenocarcinoma cell line A549 cells, H460 cells and human lung fibroblast cell line WI-38 cells. Quantitative real-time PCR (left panel) and western blotting (right panel) were repeated thrice.
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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Hamster, Cattle, Dog, Human, Monkey
Clone
CBFYM-2714
Antibody Isotype
IgG1
Application
WB, IP, ELISA, IF

Basic Information

Specificity
Mouse, Rat, Hamster, Cattle, Dog, Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-276

Target

Full Name
Metastasis Associated 1 Family Member 2
Introduction
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Entrez Gene ID
Human9219
Mouse23942
Rat361724
Dog476057
Monkey718772
Cattle515389
Hamster100752944
UniProt ID
HumanO94776
MouseQ9R190
RatB2GV01
DogE2R655
MonkeyF7EC89
CattleQ1RMW3
HamsterA0A3Q0CGV2
Alternative Names
Metastasis Associated 1 Family Member 2; Metastasis Associated Gene Family, Member 2; P53 Target Protein In Deacetylase Complex; Metastasis-Associated 1-Like 1; MTA1-L1 Protein; MTA1L1
Function
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Biological Process
Chromatin assembly or disassembly Source: ProtInc
Chromatin remodeling Source: ComplexPortal
DNA methylation Source: Ensembl
Histone deacetylation Source: ComplexPortal
Negative regulation of transcription, DNA-templated Source: ComplexPortal
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell fate specification Source: ComplexPortal
Regulation of fibroblast migration Source: Ensembl
Regulation of stem cell differentiation Source: ComplexPortal
Cellular Location
Nucleus

Li, A., Guo, Y., Yin, Z., Liu, X., & Xie, G. (2023). MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5. Journal of Cancer, 14(2), 262.

Dai, S. L., Wei, S. S., Zhang, C., Li, X. Y., Liu, Y. P., Ma, M., ... & Shan, B. E. (2021). MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E‐Twist feedback loop. Cancer Science, 112(3), 1060-1074.

Lin, C. L., Ying, T. H., Yang, S. F., Chiou, H. L., Chen, Y. S., Kao, S. H., & Hsieh, Y. H. (2021). MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis. Cell Death & Disease, 12(5), 451.

Tao, D., Zhang, Z., Liu, X., Zhang, Z., Fu, Y., Zhang, P., ... & Jiang, H. (2020). LncRNA HOTAIR promotes the invasion and metastasis of oral squamous cell carcinoma through metastasis‐associated gene 2. Molecular Carcinogenesis, 59(4), 353-364.

El-Nikhely, N., Karger, A., Sarode, P., Singh, I., Weigert, A., Wietelmann, A., ... & Savai, R. (2020). Metastasis-associated protein 2 represses NF-κB to reduce lung tumor growth and inflammation. Cancer Research, 80(19), 4199-4211.

Chen, Y. S., Hung, T. W., Su, S. C., Lin, C. L., Yang, S. F., Lee, C. C., ... & Tsai, J. P. (2019). MTA2 as a potential biomarker and its involvement in metastatic progression of human renal cancer by miR-133b targeting MMP-9. Cancers, 11(12), 1851.

Hsu, W. H., Chiou, H. L., Lin, C. L., Kao, S. H., Lee, H. L., Liu, C. J., & Hsieh, Y. H. (2019). Metastasis-associated protein 2 regulates human hepatocellular carcinoma metastasis progression through modulating p38MAPK/MMP2 pathways. Journal of Cancer, 10(26), 6716.

Tseng, T. Y., Chiou, H. L., Lin, C. W., Chen, Y. S., Hsu, L. S., Lee, C. H., & Hsieh, Y. H. (2019). Repression of metastasis‐associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p‐cofilin‐1/LC3‐II expression. Journal of Oral Pathology & Medicine, 48(10), 959-966.

Guan, C., Chang, Z., Gu, X., & Liu, R. (2019). MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway. Biochemical and biophysical research communications, 515(1), 112-118.

Si, W., Liu, X., Wei, R., Zhang, Y., Zhao, Y., Cui, L., & Hong, T. (2019). MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. Cell Death & Disease, 10(3), 206.

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For research use only. Not intended for any clinical use.

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