Mouse Anti-MTF2 (AA 103-327) Recombinant Antibody (CBFYM-2735) (CBMAB-M2928-FY)

Name: Mouse Anti-MTF2 (AA 103-327) Recombinant Antibody (CBFYM-2735)
SKU: CBMAB-M2928-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2735

Application

Immunogen

This PCL2 antibody was raised against a recombinant protein corresponding to amino acids 103-327 of mouse PCL2

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 103-327

More Infomation

Target

Full Name

METAL RESPONSE ELEMENT BINDING TRANSCRIPTION FACTOR 2

Introduction

MTF2 is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. Gene Ontology annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19.

Entrez Gene ID

22823

UniProt ID

Q9Y483

Alternative Names

Metal Response Element Binding Transcription Factor 2; Metal-Response Element DNA-Binding Protein M96; Metal Regulatory Transcription Factor 2; Tudor Domain Containing 19A; Polycomb-Like Protein 2; Polycomb-Like 2; HPCL2

Function

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557).

Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity).

Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity).

Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity).

In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity).

Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Chromatin organization Source: GO_Central
Negative regulation of histone H3-K27 methylation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of histone H3-K27 methylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Segment specification Source: UniProtKB
Stem cell differentiation Source: UniProtKB
Stem cell population maintenance Source: UniProtKB

Cellular Location

Nucleus
Note: Localizes to chromatin as part of the PRC2 complex.

Ngubo, M., Moradi, F., Ito, C. Y., & Stanford, W. L. (2023). Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2. Genes, 14(10), 1879.

Tang, C., Lv, Y., Ding, K., Cao, Y., Ma, Z., Yang, L., ... & Cao, X. (2023). Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human Tumors. Current Problems in Cancer, 47(3), 100957.

Caballero Gomez, A. (2023). Characterizing the Molecular Role of MTF2 in Refractory AML and Hematopoiesis (Doctoral dissertation, Université d'Ottawa/University of Ottawa).

Meng, X., Zhang, Y., Hu, Y., Zhong, J., Jiang, C., & Zhang, H. (2021). LncRNA CCAT1 sponges miR-218-5p to promote EMT, cellular migration and invasion of retinoblastoma by targeting MTF2. Cellular Signalling, 86, 110088.

Sun, F., Cheng, Y., Riordan, J. D., Dupuy, A., Dubois, W., Pisano, M., ... & Janz, S. (2021). WDR26 and MTF2 are therapeutic targets in multiple myeloma. Journal of Hematology & Oncology, 14(1), 1-7.

Wu, T. T., Cai, J., Tian, Y. H., Chen, J. F., Cheng, Z. L., Pu, C. S., ... & Zhang, K. M. (2019). MTF2 induces epithelial-mesenchymal transition and progression of hepatocellular carcinoma by transcriptionally activating snail. OncoTargets and therapy, 12, 11207.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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